Holders Liverpool are being tested by Genk in the Champions League. There's also plenty of EFL action to keep up with so follow it all with us right here.
Charlie Nicholas is looking ahead to the Europa League fixtures involving Manchester United, Arsenal and Wolves and gives us his predictions.
Gareth Jones, George Pitts, Tom Carnduff and Tom McDermott discuss the big talking points from the latest round of Premier League games.
Dele Alli insists Spurs players remain "1000%" behind Mauricio Pochettino and the reaction to their start to the season has been overblown.
Pep Guardiola praised the "extraordinary" Raheem Sterling after his 11-minute second-half hat-trick in the Champions League.
Chelsea travel to Dutch champions Ajax for their third Champions League group match on Wednesday evening.
Most Read Football
Mandzukic's wage cut and Villa and Palace fighting it out for Rangers' Morelos dominate Wednesday's football gossip.
Best bets and stats for Wednesday's Champions League group stage action, including Liverpool and Chelsea's clashes.
Check out Sporting Life's best bets across racing, football and more.
Sky Bet have enhanced the odds on a 10/1 goalscorer treble on Wednesday's Champions League action, exclusively for Sporting Life readers.