Top seed Roger Federer crashed out of Wimbledon after a marathon five-set shoot-out with big-serving Kevin Anderson in the quarter-finals.
Novak Djokovic has now been installed as the favourite to win the competition at 5/4 with Sky Bet, while Anderson is 7/1 after booking his place in the last four.
Eight-time champion Federer was two sets up and had a match point in the third, but almost three hours later he trudged off on the end of a seismic 2-6 6-7 (5/7) 7-5 6-4 13-11 upset.
Federer found himself scheduled on Court One having been ousted from his usual Centre Court domain for the first time in three years. But he found himself in even more unfamiliar territory with an inspired Anderson's relentless, thudding serve eventually overpowering the 20-time grand slam winner.
Federer, 36, said of SW19: "Of course the goal is to come back here next year. I wouldn't call it 'unfinished business'. I felt like I did some good business here in the past already.
"So I'm all right. I'm just disappointed now."
"I'm not quite sure what to say, I had to try my best to keep fighting," 32-year-old Anderson told the BBC.
"I scraped through the third and fourth sets and by the end I thought I did a great job. Beating Roger Federer will be one to remember, certainly in such a close match.
"I just kept telling myself to keep believing and that today it would be my day, that's the mindset you need against someone like Roger. I just gave it my all and I'm ecstatic to get through that."