Nicky Henderson's horse was sent off the 8/15 favourite and was high up in the lists for both the Sky Bet Supreme and JCB Triumph Hurdle, but he wasn't travelling well at an early stage.
To his credit he battled into contention and was still in with a chance when falling two from home, although Master Blueyes was going the better under Tom Bellamy, deputising for the injured Wayne Hutchinson.
Alan King's grey took up the running from Evening Hush between the final two flights and ran away for an easy 11-length success.
Master Blueyes was brushed aside by Charli Parcs the last time they met at Kempton earlier in the season.
Bellamy was thrilled with the winner's performance.
He said: "He was impressive and it all went to plan. I think I had the Henderson horse beaten when he fell.
"To be fair to my lad, he went away and did it professionally - he didn't look around. He has just been keen in the past, but he settled supremely well.
"It is definitely up there (as one of my biggest wins). I love riding big winners for the boss. It is a shame for Wayne Hutchinson as he missed one today and one yesterday, but it is just one of those things."
King was suitably impressed and Master Blueyes now looks likely to the tackle the Triumph Hurdle at next month's Cheltenham Festival.
The trainer said: "I've never known a horse to come on so much from Ludlow. It just gave him confidence. We were never going to come here.
"Last week I rang one of the members of the syndicate saying we are going to the Adonis to see if he is a Triumph Hurdle horse, and he most definitely is. I've just been thrilled with him the last week to 10 days.
"When he got beat at Christmas by Charli Parcs, he had just come back from a hold up as he pulled a muscle when he ran at Wetherby.
"We know he is progressive and better ground helps as well. The favourite looked in a bit of bother anyway.
"We didn't have a proper Triumph Hurdle horse and I think we've found one. It is great for Tom Bellamy, he gave him a lovely ride."
Sky Bet, who are Non Runner No Bet on all races at the Cheltenham Festival, go 10-1 from 14s about Master Blueyes for the Triumph.
