5/4 favourite with the sponsors for the weekend feature, the four-year-old was a bumper winner in France. Bought by JP McManus, she made a winning British debut for the Seven Barrows team in a maiden hurdle at Uttoxeter earlier this month.
Henderson said: "Dame De Compagnie is a lovely filly and will go for the Sky Bet Supreme Trial Novices' Hurdle at Cheltenham on Sunday. She won very easily at Uttoxeter recently, although it probably wasn't much of a race."
Also engaged on Sunday is Slate House (Colin Tizzard, 7/4), who was sold for £260,000 at Cheltenham in March and made the perfect start to his career under Rules when winning at the course on October 27.
The trainer could also be represented by Vision Des Flos (6/1) who won a valuable bumper at Punchestown in April for former trainer Robert Tyner and was third on his first start for Tizzard in the Persian War Novices' Hurdle at Chepstow last month.
Other notable entries include Lalor (Richard Woollacott, 6/1), who scored in Grade Two bumper company at Aintree in April and Western Ryder (Warren Greatrex, 8/1) who was fifth in the Weatherbys Champion Bumper at the Cheltenham Festival.
Both have run over hurdles already this season, with Lalor finishing second, beaten a short-head, at Exeter on his reappearance while Western Ryder got no further than the third hurdle at Stratford on earlier this month when the saddle slipped.
Michael Shinners, Racing PR Manager at Sky Bet, commented: "Sky Bet is delighted to be sponsoring for the fifth successive season our 'Road To Cheltenham' series, which culminates with the Sky Bet Supreme Novices' Hurdle.
"Sunday's race has thrown up some decent winners over the years, most notably Altior two years ago, who went on to win the Sky Bet Supreme Novices' Hurdle. This year's race looks set to be a cracker with several contenders already on the scoresheet this season."
Sky Bet Supreme Trial Novices' Hurdle, Sky Bet odds: 5/4 Dame De Compagnie; 7/4 Slate House; 6/1 Lalor, Vision Des Flos; 8/1 Western Ryder; 12/1 Bedrock; 16/1 Whatmore; 20/1 Better Getalong, Monty's Award, Summerville Boy; 250/1 Cassivellaunus
The races in the Sky Bet's "Road To Cheltenham" for the 2017/18 season are:
Sky Bet Supreme Trial Novices' Hurdle (Grade Two) - Cheltenham, Sunday, November 19, 2017
Sky Bet Supreme Trial Novices' Hurdle (Grade Two) - Ascot, Friday, December 22, 2017
Sky Bet Moscow Flyer Novice Hurdle (Grade Two) - Punchestown (Ireland), Saturday, January 13, 2018
Sky Bet Supreme Trial Rossington Main Novices' Hurdle (Grade Two) - Haydock Park, Saturday, January 20, 2018
Sky Bet Supreme Scottish Trial Novices' Hurdle - Musselburgh, Sunday, February 4, 2018
Sky Bet Dovecote Novices' Hurdle (Grade Two) - Kempton Park, Saturday, February 24, 2018
Sky Bet Supreme Novices' Hurdle (Grade One) - Cheltenham, Tuesday, March 13, 2018
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