Timo Werner gave RB Leipzig the advantage in their Champions League tie with Tottenham as the Germans earned a 1-0 first leg win in north London.
The visitors were the better side throughout and could have scored more than the single goal as they bossed proceedings from the start, although Spurs did rally late on when Jose Mourinho made changes.
In the end it was just Werner's penalty that was the difference, mainly thanks to Hugo Lloris, and Spurs will probably feel relieved that they only trail by one heading to Germany for the return leg.
RB Leipzig made an excellent start at Tottenham Hotspur Stadium and almost took the lead in the second minute.
A dominant display from Leipzig 💪@petercrouch, @rioferdy5 and @GlennHoddle reflect on a disappointing night for Tottenham...
— Football on BT Sport (@btsportfootball) February 19, 2020
Big improvements needed in the second leg! pic.twitter.com/3p6yxyiRMB
After Davinson Sanchez had crucially blocked a goalbound effort, on-loan Manchester City wing-back Angelino was first to the follow-up and saw his shot pushed onto the post by Lloris.
The danger was not over for Spurs, but the offside flag eventually brought them some respite when Werner had been picked out in a good position inside the penalty area.
Lloris was needed again in the 36th minute to deny Werner, who could only fire his close-range effort straight at the Tottenham captain.
RB Leipzig continued to dominate possession, although Sanchez remained a key figure in defence for the hosts, making a number of blocks and interceptions at pivotal moments.
"I want to stay positive."
— Football on BT Sport (@btsportfootball) February 19, 2020
"There is a second leg. We still have a chance."
"Let's try to create another story."
Man of the Match Hugo Lloris is staying optimistic despite Tottenham losing at home to Leipzig...
🎙 @DesKellyBTS pic.twitter.com/1cBms147Cl
Leipzig were presented with a great chance to take the lead in the 56th minute, when Spurs left-back Ben Davies clumsily brought down Konrad Laimer in the penalty area.
The Welshman received a booking and Werner, who had chipped the ball into the path of his team-mate, stepped up to take the spot-kick.
The German international fired the penalty into the bottom corner, ending his five-game goal drought and leaving Tottenham with an uphill task for the remainder.
It should have been 2-0 in the 62nd minute, when RB Leipzig caught Spurs on the counter-attack.
A wonderful dummy by Werner, from Angelino's pass, gave Patrik Schick a clear shot on goal, but Lloris produced another superb save.
Jose Mourinho reacted with a double substitution in the 64th minute, with Dele Alli and Gedson making way for Tanguy Ndombele and Erik Lamela.
Lo Celso struck the woodwork in the 72nd minute from a curling free-kick, with RB Leipzig goalkeeper Gulacsi getting a decisive touch.
Lucas Moura squandered a golden opportunity with two minutes left, when he headed over Davies' cross from close range.
Ndombele and Lamela made a difference from the bench for Spurs, but the home side had been frustrated by Gulacsi and the RB Leipzig defence.
It would prove Tottenham's final chance of the night, with referee Cuneyt Cakir blowing the full-time whistle after five minutes of stoppage time to leave Spurs with a one-goal deficit ahead of the return leg in Germany.