Seamer Pat Brown will miss the limited-overs leg of England's tour of South Africa with a low back stress fracture.
The Worcestershire player, who made his England Twenty20 debut earlier this winter, sustained the problem while preparing to feature in the Big Bash League for Melbourne Stars.
Brown will not play again this winter and will now return to Worcestershire to start his rehabilitation programme.
An England statement added: "England will announce a replacement for the three-match ODI series and for the three IT20s against South Africa in due course."
