Derek Chisora will face David Price at The O2 on Saturday October 26, live on Sky Sports Box Office in the UK and DAZN in the US.
Chisora was scheduled to face former WBO world champion Joseph Parker until the New Zealander was forced out through illness, and will now face Price.
Chisora returns to the ring three months on from his emphatic second-round stoppage of Artur Szpilka for what will be his sixth bout in succession in Greenwich, a run which includes his battle with Dillian Whyte and a knockout victory over Carlos Takam.
Price, who was due to fight in Liverpool on November 23, steps in to face Chisora on the back of his victory Dave Allen at the same venue.
"It didn’t matter who got in the ring with me on October 26th I’m ready for war," said Chisora.
"David Price has stepped up and I’m ready for whatever he brings. If he thinks I’m just going to stand there and be a punch bag like Dave Allen he is in for a shock."
Price was rather more circumspect, saying: "I'm very excited.
"Derek is a great competitor and I’m sure he’ll bring the best out of me. I kept in the gym all summer because I had a feeling I had to be ready for a call like this, and ready I am."