Fury got his hands on one of the four major world belts again when he ended Wilder's long reign as champion, knocking the previously-unbeaten American down twice en route to a seventh-round stoppage in February.
While he is contractually obliged to face Wilder for a third time and Joshua is scheduled to take on Kubrat Pulev next, the outbreak of coronavirus and subsequent suspension of major boxing shows has clouded the issue.
Speculation is rife a domestic dust-up could take priority but Lee can only see one outcome in a fight which would determine the undisputed world heavyweight champion.
"I think (Joshua) is still an improving fighter," Lee told The Boxing Show on Sky Sports. "A little bit of inexperience and mentally he's not as strong as Tyson.
"I think Tyson would beat him in eight rounds. I like Anthony Joshua, I think he's a great fighter, a great champion.
"I still think it's a great fight and a great match-up and it's the only real match-up in the heavyweight division left for both guys, but I think Tyson wins in a similar fashion to what he did to Wilder."
Lee was brought into Fury's camp ahead of the Wilder rematch and it was the former WBO middleweight champion who suggested Javan 'SugarHill' Steward taking the lead as head trainer ahead of the bout.
The new coaching set-up proved highly successful as Fury delivered arguably the finest performance of his career.
Such was the one-sided nature of the contest, Lee believes Wilder would be unwise to jump straight back in with Fury.
"Everything is in open play again, whatever fights were made before the lockdown kind of become null and void in that everything is up for renegotiation again," Lee added.
"If I was in Wilder's team, I would say 'take another fight, maybe Andy Ruiz or somebody else, and get a win, get your confidence back up and try to improve then come back and fight Tyson again for the trilogy'.
"If they fight again, I can only see it going the same way, if not even more emphatic for Tyson."
