Leading 2000 Guineas contender Publish will miss the opening classic of the season after he was found to be lame.
Publish had been well backed in recent weeks and was a top price of 9/2 to provide the Gosden stable with a first win in the 2000 Guineas.
However, a statement from owners Juddmonte on Friday morning read: "Unfortunately, Publish was found to be lame yesterday. Early indication has suggested he will need a number of weeks out of work, which means he will not be ready for early season targets. A further veterinary examination will be required to determine when he will get back to the racecourse."
The setback means a further shake up to the 2000 Guineas market a day after Gewan, the champion two-year-old of 2025, suffered a fatal injury during a racecourse gallop at Kempton.
The betting is headed by Bow Echo at 3/1. He won all three of his starts as a juvenile, notably beating Publish in the listed Ascendant Stakes at Haydock before landing the Group 2 Royal Lodge Stakes over the same course and distance as the 2000 Guineas.
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Charlie Appleby has trained three of the last four winners of the 2000 Guineas, including the last two with Notable Speech and Ruling Court, and he is responsible for 7/1 second favourite Talk of New York.
The 2000 Guineas takes place at Newmarket on Saturday 2 May.
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