Uruguay beat Wales 1-0 to win the China Cup final in Nanning.
Edinson Cavani, winning his 100th cap, scored the 49th-minute winner from close range.
Luis Suarez struck the post twice, while Andy King and Gareth Bale went close for Wales.
Bale, who scored a hat-trick as Wales beat China last Thursday in Giggs' first match in charge, said the team were disappointed to have lost the match but insisted they could still take plenty of positives from their trip to the Far East.
He told S4C: "Obviously it's not the result we wanted. We thought they were there for the taking. We had chances but their keeper made some very good saves as well.
Sky Bet: England are evens to beat Italy on Tuesday night
"Ultimately we're disappointed, we felt we could have got more out of the game but it wasn't meant to be.
"We'll keep learning, we'll keep trying to progress and when the major games come around in the qualifiers, we'll be ready."
As well as Giggs' debut in the Wales hot-seat, the tour afforded several players the chance to make their international debuts and others to gain further experience at the highest level, and Bale believes that can only be good for the future.
He said: "It's been important. There's a lot of positives to take out and a learning experience for us all.
"I think it will stand us in good stead for the future and I'm sure we'll win many more games."
Opta facts
- Wales have won one of their 16 matches against South American opponents in their history, a 1-0 win over Brazil in September 1991 under the management of Terry Yorath; they have drawn four and lost 11 of their other matches.
- Indeed, since that victory against Brazil, Wales have scored just one goal in seven games against South American sides (D2 L5).
- Uruguay have lost just one of their last eight International matches (W4 D3), keeping clean sheets in both China Cup games.
- Ashley Williams made his 78th international appearance for Wales – he is now level with Craig Bellamy – the only outfield players to have more caps are Gary Speed (85) and Chris Gunter (87).
- Gareth Bale has failed to score or assist in four of his last five games for Wales, although he did score three and assist once against China.
- Edinson Cavani has scored in four of his last five games for Uruguay – netting exactly once on each occasion.
