Mohamed Salah will miss the second leg of Liverpool's Champions League semi-final with Barcelona due to a concussion.
The Egypt forward suffered a head injury in Saturday's win over Newcastle and manager Jurgen Klopp said at his pre-Barca press conference he would not make the Anfield clash.
"It's a concussion so it's a case of him not even being allowed to play," said Klopp, whose side are 3-0 down after last week's first leg in Spain.
"He feels OK but it's not good enough from a medical point view, that's all."
Klopp had already conceded Salah's fellow forward, Roberto Firmino, would miss out with a muscle problem.
Liverpool have it all to do to turn around the tie on Tuesday and Klopp knows the loss of two of his most lethal weapons does not help the cause.
"There's hope and that's football," he added. "We are far away from giving up.
"Two of the world's best strikers are not available tomorrow - it doesn't make life any easier but while we have 11 players on the pitch we will try."
Defender Virgil Van Dijk and midfielder Alex Oxlade-Chamberlain were also absent from training ahead of the match.
However, Press Association Sport understands the pair were undergoing specific, tailored sessions in keeping with managing their workloads at this stage of the season.
Van Dijk has played 54 times this term for club and country while Oxlade-Chamberlain made his first appearance in over a year late last month after a serious knee injury.
Also missing were long-term injury victims Adam Lallana (muscle) and Naby Keita (groin).
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