The third round of the FA Cup has produced some surprise results over the years and this year it should be no different.
All the ties take place across the weekend, with plenty of banana skin fixtures for Premier League clubs.
Some could be distracted by their league campaigns, be it a title chase, top-four battle or relegation scrap - and their underdog opponents will not need a second invitation.
Last season we saw Sky Bet League One outfit Wigan beat Bournemouth after a replay, top-flight strugglers Stoke lost to Coventry and Arsene Wenger's Arsenal suffered a shock defeat at Nottingham Forest (below).
Who will it be this time around?
Current Premier League bottom three Huddersfield, Fulham and Southampton face Bristol City, Oldham and Derby respectively and could take their eye off the ball with league survival a priority.
Double chance four-fold?
Backing the following to win or draw their FA Cup fixture against a Premier League team produces odds of 6.89/1 with Sky Bet...
- Barnsley (v Burnley), Bristol City (v Huddersfield), Blackburn (v Newcastle) and Derby (v Southampton)
We have taken a look at all of the Premier League teams facing lower league opposition - and we want your opinion here on who will fall at the first FA Cup hurdle.
A betting preview for Saturday and Sunday's action will follow on SportingLife.com in due course. In the meantime, vote below with who you think is more likely to suffer a shock defeat this weekend...
Click the image below to check out Tom Carnduff's FA Cup outright betting preview...
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Odds correct as of 1210 GMT on 04/01/19