Monday night's Premier League contest between Everton and Manchester City and has been postponed due to further postive Covid-19 tests at the Manchester club.
The game at Goodison Park was called off just four hours before kick-off and follows on from four postive tests on Boxing Day.
Gabriel Jesus, Kyle Walker and two staff members were already self isolating after testing postive for the virus ahead of City's Boxing Day game against Newcastle.
City lodged a request to postpone the match on Monday morning with confirmation coming after a Premier League board meeting in the afternoon.
The club's first team training ground at City Football Academy will close with immediate effect for an indeterminate period, and with the squad and associated bubbles will have to undergo further testing before any decision is made for training to resume.
The fixture is only the second Premier League game to be called off due to positive tests for coronavirus. The match between Aston Villa and Newcastle, due to be played on December 4, was postponed due to cases within the Newcastle camp.
A City statement read: "After the latest round of Covid-19 testing, the club returned a number of positive cases, in addition to the four already reported on Christmas Day.
"With the security of the bubble compromised, there posed a risk that the virus could spread further amongst the squad, the staff and potentially beyond.
"Based on strong medical advice the Premier League, in consultation with both clubs, have decided to postpone the fixture.
"All positive cases involving players and staff will observe a period of self-isolation in accordance with Premier League and UK Government protocol on quarantine. "
A Premier League statement added: “The Premier League continues to have full confidence in its protocols and rules, and the way in which all clubs are implementing them.
“The League wishes those with Covid-19 a safe and speedy recovery and will rearrange the postponed fixture against Everton in due course.”
