Callum Smith will put his titles on the line for the first time when he fights Hassan N'Dam at Madison Square Garden on June 1.
The Liverpudlian will defend his WBA, WBC and Ring Championship super-middleweight belts against the former world champion N'Dam on the undercard to Anthony Joshua's bout with Andy Ruiz.
Smith said: "I've had a good camp and I'm looking forward to walking to the ring as a world champion for the first time in my career.
"I worked so hard to get where I am and now the task is to keep hold of my titles and target those big fights.
"To have my first defence at Madison Square Garden is going to be special and it's another box ticked for me personally.
"People call it the 'Mecca of Boxing' and I've always seen it as a venue that I'd love to fight at one day.
"The minute that there was a chance of it happening I pushed to make sure that I could be part of this show."
N'Dam, 35, added: "I am confident I will create a big surprise in New York.
"It is a true privilege for me to be given the chance to fight at Madison Square Garden for the first time in my life.
"At this stage of my career this is a beautiful opportunity for me to be able to change division and fight for both the WBA World and WBC Diamond titles."