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The game kicks off at 1500 GMT at the London Stadium.
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West Ham v Leicester: Team news
West Ham skipper Mark Noble is ruled out against Leicester due to a dead leg.
Winston Reid will take over as captain while Sam Byram could be recalled at right-back, freeing up Cheikhou Kouyate to move into Noble's midfield berth.
Andre Ayew is set to start in attack after scoring as a substitute at Bournemouth last weekend, but defender Angelo Ogbonna (knee) and striker Diafra Sakho (back) are still out.
Leicester's January signing Molla Wague is out for the season with a dislocated shoulder.
The defender made just one appearance - in the FA Cup defeat at Millwall in January - and has had an operation but his long-term future is unknown, with the loan from Udinese expiring in the summer.
Nampalys Mendy is rated as 50-50 to return from a knee injury which saw him miss the 2-0 win over Sevilla on Tuesday and advance to the Champions League quarter finals 3-2 on aggregate.
Teams
West Ham (from): Randolph, Adrian, Fonte, Reid, Collins, Byram, Cresswell, Masuaku, Kouyate, Nordtveit, Obiang, Quina, Antonio, Fernandes, Snodgrass, Feghouli, Lanzini, Carroll, Calleri, Ayew, Fletcher.
Leicester (from): Schmeichel, Hamer, Zieler, Simpson, Huth, Morgan, Wasilewski, Chilwell, Fuchs, King, Mendy, Drinkwater, Amartey, Ndidi, Mahrez, Gray, Albrighton, Kapustka, Musa, Vardy, Okazaki, Ulloa, Slimani.
West Ham v Leicester: Manager quotes
Slaven Bilic (West Ham)
On Mark Noble: "He is the captain and is doing everything for the club," said Bilic.
"He is exactly what a captain should be, but sometimes it is too much.
"Sometimes he takes it home and thinks about that - not only about him but about the club.
"A man can take only what he can take, basically. I spoke about that with him. He is not available for Saturday and after that we have an international break.
"I left it to him, his decision whether to go somewhere for a week and come back as strong as he was. I have no worries about Mark."
On Leicester: "I said after they changed manager what I thought about it and still I don't understand it.
"But if you talk about results and performances they got what they wanted.
"Still for me it was a bad decision, Claudio did very decently with them. But it's the nature of the job, you are the first one to pay the price.
"No one can say it was the wrong decision, the three results have been brilliant and the team looks different.
"It's a different team to four weeks ago. They played extremely well especially against Sevilla. It's a great result for them and for English football.
"In all those three games they looked very lively, three wins on the spin including qualifying for the quarter-finals of the Champions League gives them a big boost."
On comments from Jaap Stam about Reece Oxford: "I am surprised, and I'm not happy with that. He went there to play.
"The only reason for him to leave us and go on loan was to get more games than he was getting here.
"We are training very intensely here.
"Reece is a different situation because he was out injured for more than four weeks. When he was coming back, he trained individually and he played more for the under-23s. So he is not a role model for how we were training.
"But if you ask me, if I heard any feedback about the intensity of our training, it was never a question of do we train with less intensity? It was more sometimes that we train too much."
On frustration from joint-chairman David Sullivan after losing 3-2 at Bournemouth: "It was a comment on that game, and I said also we can't be happy with the way we performed and how we conceded the three goals.
"We have to improve and we have to bounce back. I am the first that wasn't happy. The players know I was not happy about the performance.
"They were not happy in the dressing room. They were frustrated. They know we didn't do well enough in that game.
"From our point of view, now we have a game against Leicester, we have to bounce back and we are ready for that."
Craig Shakespeare (Leicester)
On facing Atletico Madrid in the Champions League, to lcfc.co.uk: "Facing a team who have reached the final in two of the last three seasons is a massive challenge but it's just the kind of tie you expect in the quarter-finals of the Champions League.
"Atletico Madrid are a very good team with some fantastic individuals with experience in the competition, but we'll be ready to give everything to progress.
"It will be a brilliant occasion for our supporters and for everyone at the club but, before the players can begin to think about these games, we have Premier League matches to come that are of huge significance to our season. They will be our sole focus."
On Samir Nasri's clash with Jamie Vardy: "Jamie's not a cheat and never has been, never will be. I think Jamie responded well to the comment and we have to put it to bed. The game has gone, the referee made his decision and we have to move on."
On Vardy's return to form: "Tell me a forward who hasn't gone through that spell.
"It happens. With Jamie's reaction, you could see the joy in terms of the first goal he got. Strikers live and die by their goals but the overall performance of forwards is vitally important.
"There are some good ones (strikers) and he is proven in terms of being in the (England) squad before so he's up there with the rest of them."
West Ham v Leicester: Our prediction
Our David John writes... it starts to get a bit tricky for a football team and the management staff when owners weigh in with public opinions on the outcome of a game but David Sullivan was not happy after the Hammers flopped last week in a late loss at Bournemouth.
To be fair, Slaven Bilic has been in full agreement and wants to see a positive response from a group of players somewhat stuck in mid-table limbo at the moment but has gone four games without victory and would rather not see the season fizzle out in lame fashion.
I watched the Bournemouth highlights and was scratching my head as to why Sullivan became so annoyed rather than just irritated - plenty of teams this season have conceded a late winner.
The Hammers looked a real threat going forward and the return of Michail Antonio from his one-game suspension gave the Cherries rearguard a constant headache with his pace and willingness to shoot for goal.
Just one win at the London Stadium from their last six outings continues to be a worry for the faithful and champions Leicester, brimful of confidence after a remarkable mini-turnaround in their season, could be an eyecatching price for punters at over 2/1 to take advantage of any lingering malaise.
A bonding session in Dubai and Craig Shakespeare suddenly has them all singing from the same hymn sheet so they will attempt to ride the wave a bit further – it may have got lost in all the euphoria though they are not out the woods yet towards the bottom of the Premier League despite back-to-back victories over Liverpool and Hull.
I don’t quite buy into the view of some observers that the Foxes have recaptured their title-winning best but recent evidence suggests they are not far off and look worth a small bet at the price to transfer all that good recent work to an away fixture.
Prediction: West Ham 1-2 Leicester
West Ham v Leicester: Sky Bet odds
West Ham are Sky Bet’s 5/4 favourites for the victory with Leicester up against odds of 21/10 to extend their winning run, while the draw is a 12/5 chance. Back-to-back Premier League wins has seen the Foxes drift out to 13/2 to face relegation, while they are 33/1 to win the Champions League after reaching the quarter-finals. Andy Carroll heads the first goalscorer betting at 5/1 followed by Michail Antonio (11/2) and Jamie Vardy (6/1).
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West Ham v Leicester: Opta facts
West Ham have lost as many games against Leicester in their last five (4), as they did in the previous 25 combined (all comps).
Leicester are unbeaten in five matches in all competitions against West Ham, winning four and drawing one.
The Foxes have kept just one clean sheet in their last 21 away matches against West Ham (1-0 in August 2000), with Tim Flowers in goal for Leicester that day.
Leicester midfielder Andy King has scored in two of his last three matches against West Ham in all competitions.
Leicester are two goals away from netting their 500th Premier League goal (498 currently).
Andy Carroll (49 goals) is one goal away from 50 Premier League goals, with 29 of his goals so far coming in a West Ham United shirt.
Since his debut in September 2012, Andy Carroll has appeared in just 94 of West Ham’s 178 Premier League matches (53%) and played just 40% of possible minutes (6472).
Leicester Chave won all seven Premier League matches that they have been leading this season and are the only side yet to drop a point from a winning position.
However, Leicester haven’t scored the first goal in any of their 13 Premier League away games this season – the only side not to do this.
Craig Shakespeare has won both of his Premier League games in charge of Leicester City so far – no previous Leicester boss has won their opening three Premier League games in charge of the club.

