Manchester United are backed to spoil Arsene Wenger's final trip to Old Trafford and Manchester City are tipped to enjoy another trip to the London Stadium.
By Paul Higham
Sunday's Premier League recommended bets
For details of advised bookmakers and each-way terms, visit our transparent tipping record
West Ham v Manchester City (1415 BST Sky Sports Main Event)
If West Ham were banking on champions Manchester City taking it easy after claiming the Premier League title then last week's demolition job on Swansea proved that there'll be no let-up from Pep Guardiola.
The Spaniard has no intention of letting his side coast over the line and he's set to name another strong line-up at the London Stadium. The only hint of sentiment that could creep into Guardiola's thinking is with goalkeeper Claudio Bravo, who needs to appear in all of their four remaining games to qualify for a championship medal.
Otherwise, expect all the big guns to again be on the field for City and they showed last week how dangerous they are when the shackles are off - it could be a long, hard day for David Moyes' men.
The Hammers may have already done enough to survive given the form of Southampton and Stoke, but they are only six points clear so will still be watching nervously on Saturday as their relegation rivals play.
Adrian will start in goal as Joe Hart is on loan from City and cannot play against his parent club, which could be a blessing in disguise given that City have won their last two games at the London Stadium by an aggregate of 9-0.
City are on 98 Premier League goals and looking to be the fastest ever to 100, so they'll be keen to reach three figures on Sunday and given their dominance over West Ham that seems an almost certainty.
Score prediction: West Ham 0-3 Manchester City (Sky Bet odds: 15/2)
Best bet: Manchester City to score 2+ goals in the first half at 9/4
Alternative bet: David Silva to score and Manchester City to win at 11/4
Manchester United v Arsenal (1630 BST Sky Sports Main Event)
If Arsene Wenger was drawing up lists of venues to be art of his farewell tour then Old Trafford would not be one of them, and Jose Mourinho would certainly not make the guest list.
Mourinho and Wenger may not be at each other's throats this weekend but make no mistake Jose will not be rolling out the red carpet or getting the party food ready at Old Trafford (insert pizza pun here).
The fact Wenger will likely make a range of changes with Thursday's Europa League in mind will not help the chances of him enjoying his final visit to Old Trafford.
He will play Pierre-Emerick Aubameyang as he's cup-tied in Europe but exactly who else makes his line-up will decide how likely he is to get anything from the game.
The chances aren't great though, United did lose to bottom side West Brom in their last home game but they are one of just three visiting teams to win at Old Trafford and one of just four Premier League outfits to leave with anything other than a defeat.
Coupled with United's strong home form is Arsenal's woeful efforts on their travels this season - they've lost five Premier League away games on the spin and have won just one in nine on the road in the league.
Both sides usually find the net - Arsenal have drawn just two blanks in 12 away games while United's loss to West Brom was the second time they'd failed to score at home all season - it's 4/5 for both to again find the net.
You never know what way Jose Mourinho will go in terms of line-ups, but Alexis Sanchez starred in their FA Cup semi-final win and playing against his former club is just the sort of high-profile game the Chilean relishes.
Score prediction: Manchester United 3-1 Arsenal (Sky Bet odds: 10/1)
Best bet: Alexis Sanchez to score and Manchester United to win at 2/1
Alternative bet: Manchester United to win 3-0, 3-1 or 3-2 at 7/2
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Preview posted at 1630 BST on 27/04/2018