Cory Hill will captain Wales in the first Test against Argentina in San Juan on Saturday, with head coach Warren Gatland having made eight changes.
George North will be back starting on the wing after playing at centre in the victory over South Africa in Washington, before switching to his usual wide role following a knee injury to Steff Evans.
Worcester Warriors wing Josh Adams, who was called up as a replacement for Evans, goes straight into the Wales team to face the Pumas.
Hill is one of two co-captains on the summer tour, and will lead his country for the first time in the opening Test against the Pumas.
Adam Beard joins Hill in the second row, while Wyn Jones comes into the front row and James Davies comes in at openside flanker.
Scarlets half-backs Gareth Davies and Rhys Patchell are named at nine and 10, with Hadleigh Parkes partnering Scott Williams in the midfield. Adams and Hallam Amos complete the back three alongside North.
"We have made a number of changes for Saturday as we want to give as much opportunity to the squad as possible during this campaign," said Gatland said on the Welsh Rugby Union website.
"Last weekend was an important result in difficult conditions up in Washington and we know we have got two big tests ahead of us against Argentina. They are a side that come together full of confidence and it is important we take our opportunities.
"There is a lot of exciting youth in this squad and Saturday is a chance for them to continue building their experience on the test scene and to put a marker down."