Your main hub for preview content ahead of the Champions League quarter-final second leg, including team news, betting tips and more preview content...
Liverpool lead the tie 3-0 after first-half goals from Mo Salah, Alex Oxlade-Chamberlain and Sadio Mane at Anfield, leaving Pep Guardiola's Citizens with a mountain to climb if they want to stay in the competition.
Check out team news, odds, quotes and more stories looking ahead to the Etihad clash below...
Read: Our Champions League betting tips for Tuesday
How to follow
When: 1945 (BST) kick-off
Via the Sporting Life Score Centre - here
TV: On BT Sport 2
Past meetings
Played (competitive matches): 179
Man City wins: 45
Draws: 46
Liverpool wins: 88
Team news
Sergio Aguero could make his first start for more than a month as Manchester City seek to overturn a 3-0 aggregate deficit.
The Argentina striker returned to action following a knee injury as a late substitute in Saturday's derby loss to Manchester United.
There may still be a doubt over defender John Stones, who missed the derby with a muscle problem, but left-back Benjamin Mendy (knee) is the only definite absentee.
Sky Bet: Manchester City v Liverpool Champions League quarter-final odds
Manchester City - 1/2 Draw - 19/5 Liverpool - 5/1
Jurgen Klopp has kept his cards close to his chest in regards to Mohamed Salah's availability for the crunch match with Man City, with Liverpool set to make a late decision on the Egyptian.
The Premier League's top scorer limped off in the Reds' first-leg win with a groin problem - and it remains to be seen whether he will feature in the return leg on Tuesday after being rested for the weekend's Merseyside derby.
Captain Jordan Henderson is suspended and while young midfielder Ben Woodburn has returned to training after a month-long absence Klopp is still awaiting updates on left-backs Andrew Robertson and Alberto Moreno.
Teams
Manchester City (from): Ederson, Bravo, Walker, Danilo, Otamendi, Kompany, Stones, Laporte, Delph, Zinchenko, Toure, Gundogan, Fernandinho, De Bruyne, Sane, D Silva, B Silva, Sterling, Foden, Diaz, Aguero, Jesus.
Liverpool (from): Karius, Alexander-Arnold, Lovren, Van Dijk, Robertson, Milner, Wijnaldum, Oxlade-Chamberlain, Salah, Firmino, Mane, Mignolet, Clyne, Klavan, Masterson, Moreno, Woodburn, Kane, Jones, Ings, Solanke.
Sky Bet: Manchester City v Liverpool Champions League quarter-final odds
What they said
Pep Guardiola: "Of course to go through, you have to make the perfect game, create chances, be clinical, concede few chances - all the conditions have to be perfect. The result is tough, but we have 90 minutes and in football, everything can happen. What we are going to do is try. We don't need to talk about motivation. The way they play in every game shows what they want to do. My team is extraordinary, not comparable to many others. I will be close to them no matter what happens between now and the end of the season. It's a joy to be manager of them."
Managers' head-to-head record
Played: 13 Guardiola: 5 Draws: 1 Klopp: 7
Jurgen Klopp: “I am not interested (in the favourites tag). We are only in the lead. It is better than I expected but you all know there is still a lot of work to do. We are not thinking about who is favourite. We lost here 5-0 in the beginning of the season. The quality of City was clear. We all know about Pep, best coach in the world. It was clear they would be outstanding but there is no perfect football team in the world. They have it most consistently, that is why they will be champions, but we know they can concede goals. I don't think City will be worse next season but they are human beings, thank God. They have had two results nobody expected but we had to play our best. We will have to be at our best again."
To qualify for the semi-finals (via Sky Bet)
Manchester City - 4/1 Liverpool 1/6
Essential reading
Champions League betting tips: Man City v Liverpool & Roma v Barcelona preview, predictions, tips and TV times
All-time XIs: Pep Guardiola v Jurgen Klopp - Ahead of the Champions League quarter-final second leg, whose side is better?
Manchester City v Liverpool: Where will the Champions League quarter-final tie at the Etihad be won and lost?
Van Dijk: Klopp the 'complete manager'
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Odds correct as of 1015 BST 10/04/2018.