Saracens will launch their bid for a third successive Champions Cup title by facing Premiership rivals Northampton Saints at Franklin's Gardens.
Mark McCall's side - who are 5/2 tournament favourites with Sky Bet - have claimed back-to-back European titles, and could emulate Toulon by claiming three on the trot this term.
That bid for another place in the history books will start against Northampton (100/1) on Sunday, October 15.
Guinness PRO12 champions Scarlets (28/1) will start their European exploits by travelling to Toulon (8/1) on October 15, throwing up an immediate return to the Stade Mayol for summer signing Leigh Halfpenny.
Premiership winners Exeter Chiefs (20/1) will entertain Glasgow (66/1) at Sandy Park on Saturday, October 14, while Clermont (8/1) will face the Ospreys (80/1) in Swansea on the first weekend of action.
Beaten Premiership finalists Wasps (9/1) will travel to the Kingspan Stadium to face Ulster (40/1) on Friday, October 13.
Harlequins (80/1) will host La Rochelle (25/1) at The Stoop on October 14.
Meanwhile, holders Stade Francais will start their Challenge Cup title defence with a trip to Russia to face Krasny Yar on October 14, while Connacht will take on Frenchmen Oyonnax at Stade de Geneve in Switzerland on the same day.
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