Edinburgh ensured they would finish no lower than ninth in the Guinness PRO12 when they overcame a 17-point deficit in the final 11 minutes to beat Newport Gwent Dragons last Friday.
They end their campaign, and Hodge's spell in interim charge, at Scotstoun on Saturday and the acting head coach wants to go out on a high before stepping down to make way for Richard Cockerill.
Hodge said: "Glasgow are our biggest rivals and we need no bigger motivation than facing them on their home patch.
"We've had a good week of preparation going into this game and we've got some confidence following our late win against Dragons last week. Although we didn't perform well on the whole in that game, we showed belief in our ability and a mental resilience to get the win.
"It's been a challenging season, but we want to finish on a high while playing the open and exciting brand of rugby we're capable of producing."
Blair Kinghorn will make his first start on the wing with Phil Burleigh returning to inside centre. Sam Hidalgo-Clyne and Duncan Weir are both promoted from the bench to start in the half-back positions.
Glasgow's Gordon Reid has been handed a farewell start but Sila Puafisi and Sean Lamont will have to make do with a place on the bench.
Reid's contract expires after the game while Lamont is retiring and Puafisi is bound for Brive.
Head coach Gregor Townsend said: "It will be Gordon Reid, Sila Puafisi and Sean Lamont's last involvement with the club and we're looking to send them off on a high. I'm sure all of the leavers will get a good reception from our supporters.
"It should be a cracking game as we're playing our fiercest rivals and there is a trophy at stake."
Stuart Hogg, 24, will become the youngest player to make his 100th appearance for the Warriors, while 21-year-old Zander Fagerson becomes the youngest to reach a half-century.
The latter is joined by 18-year-old brother Matt in a starting line-up for the first time.
The injured Mark Bennett, Simone Favaro and Josh Strauss miss out on farewell appearances.