Owen Farrell has been named at fly-half for England's autumn series opener against South Africa at Twickenham on Saturday.
The Saracens playmaker starts at 10 for only the third time in the Eddie Jones era, forcing George Ford to settle for a spot among the replacements.
During his three years in charge, Jones has favoured the partnership of Ford at fly half, with Farrell at inside centre. It's a combination that has delivered two Six Nations titles.
However, as highlighted in our Autumn Internationals Talking Points, Ford has struggled for form in 2018, especially at international level.
England v South Africa: Sky Bet odds
- England Win - 4/6
- Draw - 20/1
- South Africa win - 11/10
The decision means Jones can select Ben Te'o at inside centre, which will be seen as a gamble considering the Worcester player has been limited to only 28 minutes of rugby since May due to thigh and calf injuries.
He will be partnered in the centres by Exeter's Henry Slade.
The inclusion of Te'o means Manu Tuilagi is confined to a bench role, where he will win his first cap since 2016 as an impact substitute.
Sale's Chris Ashton has failed to make the matchday 23 altogether with Jonny May and Jack Nowell preferred on the wings.
In the forwards, Mark Wilson fills the void left by an injury crisis at number eight. He will win his fifth cap in the absence of Billy Vunipola and Nathan Hughes.
Brad Shields returns at blindside flanker and Tom Curry continues in the number seven jersey in a back row containing a mere 10 caps.
Your England team, co-captained by @DylanHartley and @owen_faz, to face the @Springboks on Saturday 🌹
— England Rugby (@EnglandRugby) November 1, 2018
Preview ➡ https://t.co/zzm2cKdCHY#ENGvRSA #CarryThemHome pic.twitter.com/XKzkG2gEsq
Alec Hepburn has held off the challenge of Exeter club-mate Ben Moon to start at loosehead prop and the uncapped Zach Mercer features on the bench.
To highlight England's lack of experience, co-captain and hooker Dylan Hartley has more caps than the rest of the pack put together having made 93 international appearances.
"We've become very well organised in our set-piece and have done a lot of good work in Portugal over the last week," Jones said.
England fixtures
- November 3 - South Africa
- November 10 - New Zealand
- November 17 - Japan
- November 24 - Australia
"We have put in a new defence system and our attack looks more organised than it was on the South Africa tour.
"Against South Africa you have got the physical battle up front and then you have to be tactically smart in how you attack against them.
"We need to find ways to gain momentum, then once we find momentum, convert that to points. We are really excited to be back at Twickenham Stadium. It's been a long time and we can't wait to play in front of 82,000 fans."
