French forward Martial has been out injured since August, but he's expected to return to training during the week and make himself available for Sunday's Old Trafford showdown.
It's been a struggle for Ole Gunnar Solskjaer without Martial and a number of regular starters, but he could have a host of them back to take on the Premier League leaders.
As well as Martial, Solskjaer could have the likes of Paul Pogba, Aaron Wan-Bissaka, Luke Shaw and Victor Lindelof all returning to face the old enemy.
Pogba has not played since the Arsenal game last month and has been out in the Middle East in rehab on his foot injury, while Shaw picked up a hamstring strain in the home defeat to Crystal Palace.
If all the injured players return, it would be a huge boost to Solskjaer and his side, who have won just twice all season and have scored just five goals in eight games without Martial.