Arsenal were given their best possible tie after being drawn against CSKA Moscow in the quarter-final of the Europa League.
The Gunners advanced to the next stage of the competition after a 4-1 victory over AC Milan, winning both legs.
CSKA went through after they saw off Lyon on away goals, the sides having drawn 3-3 over two legs.
Arsene Wenger's men have been cut from 4/1 to 10/3 for the Europa League as a result, with CSKA out to 33/1 from 22/1.
Atletico Madrid, who remain favourites for the title, comfortably advanced to the next stage after an 8-1 aggregate victory over Lokomotiv Moscow.
Sporting were taken to extra-time by Plzen on Thursday night, but Rodrigo Battaglia's 107th minute strike was enough to see them through.
Simone Inzaghi's Lazio side saw off Dynamo Kyiv in the last-16, they come up against FC Salzburg next.
In the other tie, Bundesliga outfit RB Leipzig come up against Marseille as they look to challenge Atletico and Arsenal for the trophy.