Two late goals flattened Tottenham as Inter Milan came from a goal down to win their Champions League Group B opener 2-1 at the San Siro.
Spurs were ahead early in the second half thanks to Christian Eriksen's fortuitous strike.
The Denmark midfielder's first effort from the edge of the box was pushed away by Samir Handanovic but from the rebound Eriksen's deflected effort looped over the Inter goalkeeper and into the net.
Sky Bet: Tottenham 11/2 to win Group B, evens to qualify as Barca and Inter start well
Tottenham were punished for wasting a number of second-half chances as Mauro Icardi equalised for Inter with four minutes left.
The striker brilliantly volleyed in from the edge of the area from Kwadwo Asamoah's left-wing cross before Vecino completed the comeback in the final seconds.
Spurs were unable to respond and suffered a third straight defeat for the first time under Pochettino, as Inter returned to Europe's top table with a dramatic win.
Odds correct as of 2250 BST on 18/09/18