Aviva Premiership team news, statistics, kick-off times & odds ahead of this weekend's action.
Bath (6) v Saracens (1)
Date: Saturday, September 9
Kick-off time: 1400 BST
TV Channel: BT Sport
Venue: The Recreational Ground
Sky Bet odds: Bath 11/8, Saracens 8/15
Bath rugby director Todd Blackadder makes a solitary change from the team that beat Leicester last weekend. Prop Anthony Perenise makes a first start since returning to Bath from Bristol, replacing an injured Kane Palma-Newport. Wales international prop Scott Andrews, who has joined Bath from Cardiff Blues as short-term injury cover, is on the bench.
Lock George Kruis and wing Sean Maitland are ruled out of the Saracens side after suffering knocks. Maro Itoje moves from flanker to replace Kruis - Michael Rhodes starts at blindside flanker - with Chris Wyles taking over from Maitland. British and Irish Lions pair Owen Farrell and Liam Willams, meanwhile, are on the bench, with Wales international Williams poised for a first team debut.
Last season: Saracens 53 Bath 10, Bath 14 Saracens 11
Last six league matches: Bath L W L W L W; Saracens W W W W L W
Top try scorers: Max Clark (Bath) 2; Sean Maitland (Saracens) 3
Top points scorers: Rhys Priestland (Bath) 12; Sean Maitland (Saracens) 15
Exeter (8) v London Irish (4)
Date: Saturday, September 9
Kick-off time: 1500 BST
TV Channel: N/A
Venue: Sandy Park
Sky Bet odds: Exeter 1/9, London Irish 6/1
Exeter show four changes from the side beaten at Gloucester. Lions wing Jack Nowell makes his first start of the season, while prop Tomas Francis replaces Harry Williams, Mitch Lees returns to partner Jonny Hill in the second-row and flanker Dave Dennis is in for Matt Kvesic.
Irish, buoyed by an impressive opening weekend win against Harlequins on their return to the Premiership, make just one change from that Twickenham encounter. Italy international Luke McLean replaces Fergus Mulchrone at inside centre, with Mulchrone being ruled out due to a hamstring injury.
Last season: No corresponding fixture
Last six league matches: Exeter W W W W W L; London Irish L L L L L W
Top try scorers: Sam Simmonds (Exeter) 2; Tommy Bell, Brendan McKibbin, Topsy Ojo & Ofisa Treviranus (London Irish) 1
Top points scorers: Sam Simmonds (Exeter) 10; Tommy Bell (London Irish) 24
Harlequins (9) v Gloucester (5)
Date: Saturday, September 9
Kick-off time: 1500 BST
TV Channel: N/A
Venue: Twickenham Stoop
Sky Bet odds: Harlequins 4/9, Gloucester 13/8
England full-back Mike Brown will make his 282nd appearance, setting a new Quins record for the professional era, with rugby director John KIngston making four changes following the defeat to London Irish as fly-half Demetri Catrakilis, hooker Joe Gray, prop Kyle Sinckler and lock George Merrick all start.
Flanker Ruan Ackermann makes his first Gloucester start as one of four changes from the team that beat Exeter. Ackermann starts alongside back-row colleagues Lewis Ludlow and Freddie Clarke, who replaces Ben Morgan, with prop Josh Hohneck in for John Afoa and Matt Scott starting alongside Andy Symons in midfield.
Last season: Gloucester 27 Harlequins 30, Harlequins 28 Gloucester 24
Last six league matches: Harlequins W L L W L L; Gloucester W L W L L W
Top try scorers: Danny Care, Joe Marchant, Charlie Walker & Marland Yarde (Harlequins) 1; Jeremy Thrush (Gloucester) 2
Top points scorers: Danny Care (Harlequins) 5; Jeremy Thrush (Gloucester) 10
Northampton (12) v Leicester (7)
Date: Saturday, September 9
Kick-off time: 1630 BST
TV Channel: BT Sport
Venue: Franklin's Gardens
Sky Bet odds: Northampton 10/11, Leicester 10/11
Wales wing George North returns for Northampton after suffering a hamstring injury during the Lions' New Zealand tour earlier this summer, while Australia international centre Rob Horne makes his first team debut. Number eight Teimana Harrison also features but flanker Tom Wood misses out due to a shoulder problem, so Courtney Lawes switches to the back-row.
Matt Smith replaces Manu Tuilagi in Leicester's midfield, with Tuilagi facing 12 weeks out due to a knee injury. Elsewhere, England prop Dan Cole returns to the starting line-up and flanker Luke Hamilton takes over from Dominic Ryan.
Last season: Northampton 31 Leicester 36, Leicester 19 Northampton 11
Last six league matches: Northampton L L L L W L; Leicester W L W W W L
Top try scorers: Tom Wood (Northampton) 2; Johnny May (Leicester) 2
Top points scorers: Tom Wood (Northampton) 10; Jonny May (Leicester) 10
Worcester (11) v Wasps (3)
Date: Sunday September 10
Kick-off time: 1500 BST
TV Channel: BT Sport
Venue: Sixways
Sky Bet odds: Worcester 9/2, Wasps 1/8
Wasps will hope to maintain their flying start to the Aviva Premiership campaign when they tackle Worcester at Sixways.
But Wasps rugby director Dai Young is on alert for the task ahead after both sides recorded contrasting results on the Premiership's opening weekend.
While Wasps ran in seven tries - four of them from scrum-half Dan Robson - as they hit 50 points against Sale Sharks, Worcester came horribly unstuck at Newcastle, losing 35-8.
It underlines Wasps' status as firm favourites, which is further strengthened by the fact they have reeled off six successive Premiership wins against Worcester.
"Listening to (Worcester rugby director) Gary Gold's interviews after their game last weekend, they were clearly disappointed with the result, so we know they are going to come out looking to put the record straight this Sunday," Young said.
"It's not always ideal to play a team who had a disappointment the week before, especially playing them at their place.
"That is probably when they are at their most dangerous, so we know it's going to be tough for us.
"We were pleased with our first 25 minutes last Saturday. We stuck to our policies and structure, and came away with a lot of good scores.
"That has got to be our blueprint this weekend. We have to keep hold of the ball, and we know we will score tries.
"If we can play for 60 or 70 minutes like we did for the first 25 minutes last weekend, it will take a very good side to beat us."
Wasps are without injured wing Christian Wade, who scored a Premiership record-equalling six tries when they beat Worcester in April 2016, so there is a start for Marcus Watson.
Guy Thompson, meanwhile, features at openside flanker, with Alex Rieder moving to blindside and Ashley Johnson reverting to hooking duties, packing down alongside Simon McIntyre and Jake Cooper-Woolley.
Worcester show two changes from the trip to Kingston Park, with Perry Humphreys replacing wing Dean Hammond and lock Pierce Phillips making a full debut instead of ankle injury victim Will Spencer.
British and Irish Lions centre Ben Te'o also starts, being partnered in midfield by Jackson Willison, with Tom Heathcote and Jonny Arr forging Warriors' half-back combination.
Wasps are without wing Christian Wade and centre Juan De Jongh, who have hamstring and finger injuries, respectively. Marcus Watson lines up on the wing, and there is also a start for flanker Guy Thompson, with Alex Rieder moving to the blindside role and Ashley Johnson returning to the front-row as hooker.
Last season: Wasps 40 Worcester 33, Worcester 12 Wasps 26
Last six league matches: Worcester L L W L L L; Wasps W W W L W W
Top try scorers: Josh Adams (Worcester) 1; Dan Robson (Wasps) 4
Top points scorers: Tiff Eden (Worcester) 21; Dan Robson (Wasps) 20