Reigning Challenge Cup holders Catalans Dragons were dumped out of the quarter-finals of the competition by recent back-to-back winners Hull, who ran out emphatic 51-8 winners at the KCOM.
The two sides have won the last three editions of the competition between them, but it was 2016 and 2017 winners Hull who raced into a 12-0 lead inside seven minutes.
Jake Connor and Bureta Faraimo crossed for the hosts but a quickfire brace from Lewis Tierney pulled Catalans back to a 12-8 half-time deficit.
Marc Sneyd, who kicked 19 points on the night, added an early second-half penalty before tries from Sika Manu and Ratu Naulago put Hull into a commanding 26-8 lead with 25 minutes to play.
And further scores from Albert Kelly, Naulago, Jamie Shaul and Danny Houghton deservedly cemented Hull's place in the last four at the University of Bolton Stadium on July 27.
Hull, who were hammered 55-2 against Huddersfield at last week's Magic Weekend, needed just five minutes to better their feeble showing at Anfield.
The hosts grabbed an early advantage when Sneyd's high kick was contested by Naulago and Catalans winger Fouad Yaha, but neither player could gather as Connor collected the loose ball to dot down.
Hull soon extended their lead to 12-0 when a sweeping move from right to left resulted in Sneyd playing a dubious, forward-looking cut-out pass for Faraimo to stroll through in the left corner.
However, the holders hit back to cut the deficit to 12-4 as they capitalised on back-to-back infringements from Hull, working their way down the right edge for Tierney to cross in the corner.
Catalans, who were the first non-British side to win the competition in its 121-year history last year, sliced through the Black and Whites' left edge once again for Tierney to grab his second try, but Sam Tomkins missed his second conversion and that is as good as it got for the French side.
Sneyd added a 30-metre penalty five minutes into the second half to move the hosts 14-8 in front before Manu crashed over to extend the lead to 12 points.
It got even better for Hull as the Dragons looked to have men over on the left edge but a stray Kenny Edwards offload was picked off by Connor on his own 10-metre line to race clear before handing to Naulago to cross.
Kelly produced a fine dummy and step to slice through the Catalans' defence for another straightforward try before Sneyd added a drop goal to kill off any hope of a comeback from the away side.
Naulago pounced on another stray offload from Edwards to power his way over from 20 metres for his second score to put Hull into a 39-8 lead, before a fine move from Mark Minichiello and Kelly set up Shaul to score under the posts.
And Hull passed the 50-point mark late on as hooker Houghton found a gap in the Dragons' defence after a neat pass from Sneyd to seal a terrific win.