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The game kicks off at 1500 GMT at Old Trafford.
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Manchester United v West Bromwich Albion: Team news
Zlatan Ibrahimovic, Paul Pogba, Chris Smalling and Phil Jones are among the absentees for Manchester United's Premier League clash with West Brom.
Ibrahimovic and Ander Herrera serve domestic bans at Old Trafford on Saturday, when midfielder Pogba will be absent with a hamstring injury.
Defenders Jones and Smalling were forced out of the England squad after sustaining what Jose Mourinho called "long-term injuries", but captain Wayne Rooney is available. Marouane Fellaini is a doubt.
Nacer Chadli is an injury concern for West Brom ahead of their trip to Old Trafford to face Manchester United.
The midfielder has returned from international duty with the Belgium squad nursing a shoulder injury and he will be assessed along with striker Salomon Rondon, who only linked back up with the Albion squad on Friday following his World Cup qualifying exploits with Venezuela.
Matt Phillips continues to struggle with a hamstring injury and he is likely to remain out.
Man United (from): De Gea, Romero, Valencia, Fosu-Mensah, Tuanzebe, Rojo, Bailly, Blind, Darmian, Shaw, Young, Carrick, Fellaini, Mata, Lingard, Mkhitaryan, Rooney, Martial, Rashford.
West Brom (from): Foster, Myhill, Dawson, Nyom, McAuley, Kane Wilson, Marc Wilson, Evans, Galloway, Brunt, Fletcher, Field, Yacob, McClean, Chadli, Rondon, Robson-Kanu, Leko.
Manchester United v West Bromwich Albion: Manager quotes
Jose Mourinho (Manchester United)
On trying to sign new players: "If a player wants to move to London, enjoy London - we don't want you.
"If the first thing you think is where you're going to live, well, think Los Angeles.
"Galaxy would be the first choice and then Vitoria Setubal, go to the beach every day. There are beautiful places to live and to play."We want people who are really engaged with the first contact.
"We want people that if I call some guy or if Mr Woodward calls some player or some agent, we want people who are immediately engaged, immediately dreaming about coming.
"This is the profile of players we want. If you don't want to come to us, good luck, enjoy your other club."
Asked how long he expects to be without Phil Jones and Chris Smalling, he said: "I don't know, I don't know.
"I know that Zlatan and Herrera have the last match ban, so it's easy to say they will be available after the match.
"I think clearly the two English boys they are long-term injuries and Pogba I have no idea. I don't know."
On Neymar: "It's speculation. I always try to be objective and pragmatic with clubs and to ask them what they can give me. To ask for Neymar is absurd," he told ESPN.
"A club like Barcelona cannot and will not lose Neymar. Although Messi is still a young player with years ahead of him, he's almost 30, and Neymar will be the great player of Barcelona post-Messi.
"So much that I think it (trying to sign Neymar) is like trying to break into a safe; impossible."
On World Cup qualifying: "The European qualifiers make me angry. The South American qualifiers excite me. I enjoy football taken seriously, not for fun.
"In the South American qualifiers, there are a lot of good teams, on similar levels. Even those who aren't as strong as the others find some way to create difficulties.
"In Europe, the qualifiers are a joke. We qualify and who doesn't goes straight to the play-offs, where there is a brutal difference between the teams. In South America, the qualification stage is a true competition that lasts two years."
On his future: "I think after Manchester United I need an easier job, and coaching the Brazilian national team would be harder. Obviously it would be great, any coach would want to work in the best teams and national teams.
"There is a coach inside every Brazilian. In every journalist, there is a coach better than the coach. I think it must be a country that's hard to work, but also exciting. But I recognise that the Brazilian national team is for a Brazilian coach."
Tony Pulis (West Bromwich Albion)
On United's strength in depth: "If you look at United's squad, in fact at all the top-six clubs, they have some fantastic players.
"They're able to compete in all major competitions this year because they've got strong squads, they haven't just got 11 players. They've got 25 players, all internationals.
"If Jose gets a few injuries he can replace them with experienced internationals who have cost a lot of money, it'll still be a top team."
On West Brom's strong recent record at Manchester United: "It's lovely to have that record - two of the last three - but we'll need a bit of fortune again. We'll need to play to our maximum and Manchester United need to be off it a little bit.
"Sometimes it goes your way, sometimes it doesn't. We know we're playing against a club that are financially miles in front of us but you get games like that in this league and you still can manage to win games if it goes right for you."
Manchester United v West Bromwich Albion: Our prediction
Our David John writes... replete following my successful tip on a West Brom game at last, I am going to roll the dice once more on Tony Pulis’ side at Old Trafford.
The Baggies are brimming with confidence following a convincing 3-1 scoreline over Arsenal and punters have already latched onto the fact with their odds shortening up all the time in both the win market and Double Chance.
They may have enjoyed only a measly 23% in terms of possession but more than made up for that in terms of desire and commitment, an issue Pulis has been keen to highlight with continued praise for tight-knit, hard-working group of players.
The notable carrot of achieving their best-ever points tally in the Premier League is still very much dangling in front of them so expect no slackening off between now and the middle of May.
While West Brom chip away solely in the Premier League, Jose Mourinho is attempting to keep a number of balls in the air with chances to win the FA Cup and Europa League as well.
Expect the Portuguese to be in full-on whinge mode too over the next few weeks with nine games to play in April and the potential of just a few days of rest squeezed in between games for his squad.
The run-in has not got off to the best start either with United possibly without up to seven first-team regulars due to suspension and injury this weekend and West Brom are exactly the sort of team who will test out one the big guns in terms of how robust they are feeling.
As mentioned, punters feel the Red Devils could be vulnerable here and Mourinho has already given a little hint his best option when it comes to getting back into the Champions League is winning in Europe so his tip-top resources might be best deployed on that front.
I am not saying he has given up on the top four but butting horns with Liverpool, Arsenal and Manchester City will be a draining and something may have to give.
West Brom are very much in the mood to give them a nudge in the wrong direction and well up to springing another surprise.
Prediction: Manchester United 0-1 West Brom
Manchester United v West Bromwich Albion: Opta facts
Manchester United have lost two of their last three home Premier League games against West Brom (W1), this after being unbeaten in the previous seven.
Aside from those two wins, West Brom have failed to score in three of their last five league games at Old Trafford.
Wayne Rooney has scored seven goals and assisted five more in his last 10 Premier League appearances against West Bromwich Albion.
A visiting player has been sent off in two of the last three Premier League games between these two (Juan Mata in March 2016, Gareth McAuley in November 2015).
Manchester United have scored with just 9.1% of their shots in the Premier League this season; their lowest shot conversion ratio in the competition in a single season since 2004-05 (8.2%). .
The Red Devils have already had 33 more shots (463) and 26 more shots on target (170) this Premier League season than they did in the whole 2015-16 under Louis van Gaal.
West Brom have scored more goals from defenders (12) than any other Premier League team this season.
James Morrison could make his 300th Premier League appearance in this match, becoming just the fourth Scottish player to reach this landmark after Darren Fletcher, Paul Telfer and Gary McAllister.
West Brom have outrun their opponents in a league-high 93% of their matches in the Premier League this season (27/29), including the last 19 games in a row.
On the other hand, Manchester United have been outrun by their opponents in all but three of their 27 Premier League matches this season – the worst record by a Premier League side in 2016-17.
Manchester United v West Bromwich Albion: Sky Bet odds
West Brom will be in confident mood after a convincing 3-1 home win last time against Arsenal and they are 8/1 chances with Sky Bet to follow up and claim another victory at Old Trafford. The home side still have an eye on a place in the top four and can be backed 1/3 for all three points – they have lost just once at home all season. The draw is 19/5 while Marcus Rashford and Wayne Rooney head the betting at 3/1 to open the scoring with Zlatan Ibrahimovic still serving a suspension.
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