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The game kicks off at 1945 GMT at the Emirates Stadium.
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Arsenal v West Ham: Our prediction
This could turn out to be a wobbly old London derby with neither side in convincing form and the future of both managers remaining an extremely hot topic.
The Hammers are suddenly sinking very quickly after four defeats on the spin and are now just six points clear of safety following another reverse against Hull at the weekend.
A dire run in terms of injuries has hindered Slaven Bilic for some time but his side don’t help themselves as they once again squandered a winning position and the Croat’s tremendous ability from last season to make a telling tactical change seems to have deserted him.
He has received another tentative thumbs-up from the board again in the aftermath but patience is already wearing very thin and a protracted relegation fight could seal his fate sooner rather than later if some momentum is not regathered.
Their opponents romped to a 5-1 success when they met at the London Stadium before Christmas after the hosts capitulated in cringe-worthy fashion as they conceded four goals in the last 18 minutes.
Oh how Arsene Wenger would love to see something approaching that sort of display from the Gunners as their season continues to feebly fizzle out following Sunday’s unconvincing 2-2 draw at home to Manchester City.
In the plus column, they twice managed to haul themselves back level in a strange game but looked distinctly leggy towards the end and never seemed likely to go on and force the winner which might appease the ever-growing anti-Wenger lobby.
Even considering West Ham’s woes, the home side are a shockingly short price and though Bilic has lost that magic in the dugout, he won’t have to be Sherlock Holmes to figure out Arsenal can and will fold very tamely if put under some pressure.
If he and his players clear their heads, take a look at the table and realise they are not in bad shape if this is the start of a relegation struggle, they should go out with some freedom to serve it up to the hosts and make it consecutive victories at the Emirates.
Prediction: Arsenal 1-2 West Ham
Arsenal v West Ham: Opta facts
Arsenal have lost just one of their last 17 Premier League games against West Ham (W13 D3), though it did come in this exact fixture last season.
West Ham have won five Premier League away games against Arsenal – they’ve only won more on the road in the competition against Fulham (6).
Slaven Bilic could become just the third manager to win his first two Premier League visits to face Arsenal after Ron Atkinson and Guus Hiddink.
Alexis Sanchez has scored four goals and provided one assist in his last two games against West Ham, including a hat-trick in the reverse of this fixture.
Should the Gunners win it will be their 10th Premier League double over the Hammers, more than they’ve achieved against any other side in the competition (also 9 vs Everton).
Andy Carroll has scored five Premier League goals against Arsenal – against no side has he scored more in the competition (also 5 vs Swansea and Man City).
There have been four hat-tricks in Premier League meetings between these sides – Arsenal vs Liverpool is the only fixture to see more in the competition (5).
Arsenal have won just one of their last eight Premier League matches played in midweek (Tues-Thurs); drawing four and losing three.
West Ham have won six of their seven midweek Premier League games (Tuesday-Thursday) since the start of 2016 (W6 D0 L1).
No team has scored more headed goals than Arsenal in the Premier League this season (14, level with West Brom).
Arsenal v West Ham: Sky Bet odds
Arsenal are the odds-on favourites at 2/5 with Sky Bet to help ease some of the pressure on Arsene Wenger with victory at home to West Ham on Wednesday night. The Hammers are on offer at 6/1 to spring a surprise at the Emirates Stadium and the draw can be backed at 19/5. Arsenal drew 2-2 with Manchester City on Sunday and the online bookmaker offers a repeat of that scoreline at 14/1. All of the Gunners’ last five matches have contained four or goals and Sky Bet go 11/10 that this contest contains over the 3.5 goals mark (odds-on at 4/6 that it doesn’t).
Click for Sky Bet's Arsenal v West Ham odds!
Arsenal v West Ham: Team news
West Ham will welcome back Michail Antonio from a hamstring injury for Wednesday's Premier League clash with Arsenal.
Antonio will play some role in the match at the Emirates Stadium, although boss Slaven Bilic refused to indicate whether he is ready to start.
Aaron Cresswell will miss the next two games with a thigh injury but Diafra Sakho could be on the bench for the first time since suffering a back injury in November.
Arsenal will be without Laurent Koscielny after the defender was forced off at half-time in Sunday's 2-2 draw with Manchester City due to an Achilles issue, and the France international is awaiting a scan to determine the severity of the problem.
Goalkeeper Petr Cech (calf) and Lucas Perez (thigh) are also missing while Santi Cazorla (Achilles) will not play again this season, although both Aaron Ramsey and Alex Oxlade-Chamberlain could shake off knocks to be involved.
Teams
Arsenal (from): Ospina, Martinez, Bellerin, Holding, Gabriel, Mertesacker, Mustafi, Monreal, Gibbs, Maitland-Niles, Coquelin, Xhaka, Ramsey, Oxlade-Chamberlain, Ozil, Walcott, Reine-Adelaide, Iwobi, Sanchez, Giroud, Welbeck.
West Ham (from): Adrian, Randolph, Byram, Fonte, Collins, Sakho, Masuaku, Arbeloa, Kouyate, Noble, Fernandes, Nordtveit, Snodgrass, Feghouli, Lanzini, Carroll, Fletcher, Calleri, Antonio.
Arsenal v West Ham: Manager quotes
Arsene Wenger (Arsenal)
On his future: "I have answered that question many times. I can understand that you ask again. Don't worry, you will get that (answer) soon."
On if he has been given a specific Arsenal target this season: "No.
"I tell myself to finish as high as possible... It (finishing in the top four) is a good challenge but I think it's perfectly possible.
"Certainly for 20 years I have done it and it looked always like it's nothing. Suddenly it becomes important, so I am quite pleased that people realise that it's not as easy as it looks.
"If you listen to (Manchester City manager) Pep Guardiola, he said the other day that to achieve the top four in England is a trophy because it's so difficult.
"Of course we have a difficult task in front of us, but I am happy as well that people realise suddenly that it's not as easy as it looked always."
On the West Ham game: "If we show the same spirit we showed against City, we will win football games. We have played 20 games unbeaten this season, and I think it's a good opportunity to remind people we are not fighting to not go down - we are fighting to have a positive end to the season.
"That's why you want the fans to stand behind the team and that the debate at the moment is about that. Let's finish as strong as we can and show that we have some resilience, some quality and some mental spirit that we have shown against City."
On calls for him to leave Arsenal: "I'm not in politics. It's not about majority or minority. You just want our fans to stand behind the team and the club, and that's what they did. I've said many times, it's not about me.
"I love to win football games and I just focus on that. I lead with the values I think are important in life. I work for my club with honesty and integrity, and I'm not scared (of any criticism). I always accept the judgement of people, and I just focus on what I think is important in the game. That's it.
"I care about Arsenal, about the club, about what we have achieved and what we want to achieve. That's what you want to do. I will support Arsenal when I'm not here any more exactly the same (as I do now). What you want is the fans to stand behind the team.
"I wish just to dedicate my energy to football and the next game, and leave my own personal case out of the debate. What is important... I think if I've shown one thing in my 20 years, it's that I care about Arsenal, I care about the next game, and I will continue to do that as long as I'm here.
"I am professional and when you are professional, you perform in ideal conditions and non-ideal conditions as well."
Slaven Bilic (West Ham)
On Michail Antonio playing: "Antonio has trained the last couple of days. He is definitely going to be involved in the game, whether he starts or not, we'll see.
"It's a big boost for us because we are talking about our best player. He makes a difference week in and week out.
"He's been doing that all the time and it's a big boost for us ahead of a game like Arsenal."
On his own situation: "I don't have to read the papers to know my relationship with the board because I talk to the chairman before or after every game.
"It's nice to read it but I know I have the confidence from the board and I wasn't worried. I have my job, I concentrate on that and my players.
"I knew that their confidence was there before and I like it that I'm not thinking about it a lot, but totally focused on my job and the next game. That's the only way to act and think."
On the Gunners: "Arsenal have their problems, but they are still a team with a lot of pace, a team you can't afford to lose the ball against in your own half because the transition and pace they have up front is unbelievable.
"They attack with numbers which makes them more likely to create something, but when they lose the ball they are very vulnerable because they leave a big space behind which you can use."