Elliot Daly will start England's non-cap international against the Barbarians at full-back, with Danny Cipriani having to settle for a place among the replacements.
It is Daly's first start in the number 15 jersey, having made all but one of his previous England appearances on the wing, and the selection sees Mike Brown - the usual incumbent in the position - switch to the left wing.
Cipriani has been overlooked for a starting role despite his return to the senior England squad, with George Ford preferred at fly-half.
The team for Sunday's match at Twickenham is co-captained by Ford and Chris Robshaw, and the latter is joined in the back row by Tom Curry, the Sale openside who appears destined to fill the seven jersey for next month's series against South Africa.
Scrum-half Ben Youngs is back in an England jersey for the first time since suffering a serious knee injury against Italy in the NatWest 6 Nations opener in March.
There are four uncapped players in the starting XV in centre Henry Trinder, hooker Jack Singleton, lock Elliott Stooke and number eight Zach Mercer.
The Barbarians fixture serves as a warm-up for three-Test series against South Africa that takes place in Johannesburg, Bloemfontein and Cape Town.
"This is a good young squad and their work ethic has been outstanding over the last two weeks," head coach Eddie Jones said.
"Their application to learn has been very good but they are very young at Test level so this week's match against the Barbarians is a fantastic opportunity for them to step up.
"It is a great opportunity for them to show they deserve to wear the English rose, to show they can be in contention for the World Cup and a great opportunity for them to put us on the front foot ahead of the South Africa tour.
"As last year, Chris Robshaw and George Ford will co-captain the side. Their combined experience and expertise gives us the best captaincy level for the game."