Jack Maddocks, Tom Banks, Folau Fainga'a, Caleb Timu and Brandon Paenga-Amosa all feature among a group that sees flanker Michael Hooper named as captain.
The Wallabies face NatWest 6 Nations champions Ireland in Brisbane on June 9, followed by a June 16 clash in Melbourne and then Sydney on June 23.
The Sydney-based Waratahs provide the biggest single representation with 10 players, while Cheika has also named a batch of seasoned international campaigners in the likes of Hooper, David Pocock, Israel Folau, Will Genia and Bernard Foley.
It will be the first time that Australia and Ireland have met in a three-Test series, while Ireland have not beaten the Wallabies in Australia since 1979.
Australia squad for Test series against Ireland.
Backs: T Banks, K Beale, I Folau, B Foley, W Genia, D Haylett-Petty, R Hodge, S Kerevi, M Koroibete, T Kuridrani, J Maddocks, S Naivalu, N Phipps, J Powell, C Rona.
Forwards: A Alaalatoa, R Arnold, A Coleman, F Fainga'a, N Hanigan, M Hooper (capt), S Kepu, B Paenga-Amosa, D Pocock, T Robertson, R Simmons, S Sio, I Rodda, C Timu, L Tui, T Tupou, J Uelese.
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