Hull will be without eight first-team players for the derby with Hull KR after discovering the full cost of their feisty Ladbrokes Challenge Cup win at Featherstone.
Coach Lee Radford says prop Josh Bowden is expected to miss the rest of the season after sustaining knee ligament damage, while winger Fetuli Talanoa and centre Carlos Tuimavave will be sidelined for the next 10 weeks with ankle injuries.
They join prop Brad Fash and half-backs Marc Sneyd, Albert Kelly and Jordan Abdull on the casualty list, with none of them likely to be back in the short term. Leading scorer Sneyd could be out for another 12 weeks with a knee injury.
The Black and Whites have also been hit by a two-match ban imposed on winger Bureta Faraimo following his dismissal for a high tackle at Featherstone.
However, Radford has confirmed that front-row pair Scott Taylor and Mickey Paea are set to return against their former club on the second day of the Dacia Magic Weekend at St James' Park, and Jack Logan has recovered from a leg injury.
The club have been linked with a move for Castleford forward James Green and are reported to be considering bringing centre Kirk Yeaman out of retirement to help them through their injury crisis.