Roger Charlton's Quadrilateral faces eight rivals in the Group One bet365 Fillies' Mile at Newmarket on Friday.
The QIPCO 1000 Guineas favourite is unbeaten in two starts and made a huge impression at Newbury last time out when winning a conditions race by a startling nine lengths.
Jessica Harrington's Cayenne Pepper heads the opposition, the Australia filly winning the Group Three Flame Of Tara Stakes at the Curragh on her latest start.
Harrington is aiming to win her third Group One in the last two weeks with her juvenile fillies thanks to the successes of Millisle in the Cheveley Park and Albigna in the Prix Marcel Boussac.
The other Irish challenger is Love from the Aidan O'Brien yard.
Hugo Palmer's Powerful Breeze goes into the race on the back of her Group Two win in the May Hill Stakes at Doncaster last month, while John Gosden and Roger Varian also run last-time out winners in Anastarsia and Queen Daenerys respectively.
Ananya, Boomer and West End Girl complete the field.
Mustashry up for the Challenge
Sir Michael Stoute's Mustashry will aim to regain the winning thread in the Group Two Godolphin Stud & Stable Staff Awards Challenge Stakes at Newmarket on Friday.
The six-year-old won the Joel Stakes at last year's Cambridgeshire meeting at the same track and landed his first Group One in this season's Lockinge, but has been found wanting at that level subsequently in two starts (the Queen Anne and Coral-Eclipse).
After 97 days off the track since Sandown he drops in class and trip, but does have a Group One penalty to shoulder following his Newbury win.
The three-year-old Shine So Bright heads the opposition, Andrew Balding's horse being on a retrieval mission of his own after defeat in the Park Stakes at Doncaster last time.
He won the European Free Handicap over Friday's course and distance earlier in the season and beat Laurens by a nose in the Sky Bet City of York Stakes at the Ebor Festival.
Limato is going for his third successive win in this race for Henry Candy, Ryan Moore taking the ride on the horse for the first time in four years.
Richard Hannon's Oh This Is Us and William Haggas' Solar Gold complete the line-up.