Sky Bet cut Mister Fisher to 12/1 for the JLT Novices' Chase at the Festival after he landed the Ryman Novices' Chase at Cheltenham on Saturday.
Nicky Henderson's horse was well backed into 15-8 favouritism as stablemate Champagne Platinum drifted and the market got it spot on.
Champagne Platinum was slow and deliberate at his fences and was tailed off, while Mister Fisher travelled into contention nicely sitting off the pace set by Good Boy Bobby.
Nigel Twiston-Davies' horse jumped and ran well off the front end, but he always looked like he might be a sitting duck for Mister Fisher up the hill and so it proved.
Henderson said of the winner: "He was good. As Nico (de Boinville) said, that is not his ground as it has got quite a lot softer today.
"He was good (jumping), although he got a bit low at one which frightened me, but it is amazing how much experience counts.
"The Warwick run brought him on considerably.
"I think that's his trip. He was a good hurdler, but he has grown a lot through the summer.
"He will be a better horse on better ground. I think we will go somewhere else and have a look and see, but hopefully he might be a JLT horse."
Treble for Henderson
The Seven Barrows handler went on to complete a treble on the afternoon, with Call Me Lord justifying 2-1 favouritism in the Unibet International Hurdle under James Bowen and Dame De Compagnie also scoring at 2-1 in the concluding Park Mares' Handicap Hurdle in the hands of Barry Geraghty.
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