Altior is the star attraction among the eight entries for the bet365 Celebration Chase at Sandown on Saturday.
Nicky Henderson's crack novice is unbeaten in five starts over fences, the latest coming in the Arkle Trophy at Cheltenham.
However, this will not be the first time he has taken on seasoned campaigners as he trounced subsequent Grade One winner Fox Norton in the Game Spirit Chase at Newbury in February.
Henderson has also put Josses Hill, Theinval and Vaniteux in the two-mile feature which was reopened due to insufficient interest.
Altior's main rival is likely to be Special Tiara, who narrowly defeated Fox Norton in the Queen Mother Champion Chase at Cheltenham last month.
Henry de Bromhead's charge took this prize two years ago at the chief expense of the Henderson-trained Sprinter Sacre, who won the race last season.
Paul Nicholls can choose from As De Mee and San Benedeto, while Tom George has left in God's Own.
