The New York Islanders scored three goals in the third period but could not complete the comeback as they lost 7-6 to the Tampa Bay Lightning.
The Lightning were 3-1 up after 20 minutes and then fired four goals in the second, including two from JT Miller.
A brace from Anthony Beauvillier in 75 third-period seconds brought the Islanders to within a goal, but the playoff-bound Lightning held out for the win.
The Vegas Golden Knights have broken the 100-point barrier in their first season in the NHL.
The side lost in overtime to the San Jose Sharks 2-1 as they gained the single point needed to reach the milestone.
It is the first time in league history an expansion team has reached triple figures, with the Knights holding a record of 47-21-6 as they sit on top of the Pacific Division.
Meanwhile, the Arizona Coyotes and Carolina Hurricanes were also in the goals - with a Jeff Skinner score on 18:02 in the third the difference as Carolina prevailed 6-5.
The Hurricanes were already 2-0 up after five minutes but had the lead cut in half in bizarre circumstances in Raleigh - after the puck got stuck in the goalie's skate and he crossed the line.
Carolina's Cam Ward was behind the net as he went to play the puck and did not notice it had got lodged in his right skate.
Ward returned to the net and crossed the line - and the goal was awarded to Alex Goligoski following a video review.
Anze Kopitar scored four goals - the fifth player to strike four times in a game this season - in the LA Kings dominating 7-1 win over the Colorado Avalanche.
Stanley Cup winner (odds via Sky Bet)
- Nashville Predators - 5/1
- Tampa Bay Lightning - 5/1
- Boston Bruins - 6/1
- Vegas Golden Knights - 15/2
- Toronto Maple Leafs - 11/1
- Washington Capitals - 11/1
Elsewhere, the New York Rangers went down to the Philadelphia Flyers 4-3, and the Columbus Blue Jackets won their 10th straight game as the side beat the Florida Panthers 4-0.
The Edmonton Oilers were slick as they beat the Ottawa Senators 6-2 and Detroit Red Wings are officially out of the playoffs after losing to the Washington Capitals 1-0.
The Toronto Maple Leafs beat the Nashville Predators 5-2, while fellow Canadians the Vancouver Canucks also recorded the same scoreline against the Chicago Blackhawks.