Two of the NFL's best-known quarterback have both suffered significant injuries, with Pittsburgh Steelers losing Ben Roethlisberger for the entire season while Drew Brees will be out for six weeks for the New Orleans Saints.
Roethlisberger need surgery on an elbow injury he picked up in the home loss to the Seattle Seahawks on Sunday, and will be forced to sit out the entire campaign as a result.
The 37-year-old has already previously hinted at retirement and it remains to be seen if the two-time Super Bowl winner will return to action given the amount of time he'll be forced to miss.
40-year-old Brees is also a Super Bowl champion and has only ever missed one game through injury in his career, but he damaged ligaments in his throwing thumb during their loss at the LA Rams and will also need surgery.
His return is not firmly known but six weeks is the tentative time given for his return to action but, again, given his age the veteran may take longer to get back onto the field.
The injuries take two of the most prolific and durable quarterbacks out of the league for the first time since the end of 2004 - which is the last time an NFL week of games failed to feature either Roethlisberger or Brees in action.
Either Roethlisberger or Brees have been the top passing yards leaders in the NFL for six of the last eight seasons, with them tying for the honour in 2014, and both are huge influences and leaders for their respective teams.