Rose was among the favourites for the year's first major thanks to a superbly consistent record at Augusta National which included two second places in the previous four years and a total of 11 top-25 finishes in 13 appearances.
However, the world number two could only manage rounds of 75 and 73 to miss the cut by a single shot after crucially dropping shots on the 17th and 18th in the second round.
"I think I got my preparation a little bit wrong," Rose told a press conference ahead of his return to action in the Wells Fargo Championship at Quail Hollow.
"I took a month off in February and that was designed to really freshen me up going into Augusta and for the rest of the season. I kind of came out of that month not playing as well as I would have hoped and the Florida Swing became a bit of a struggle and a bit of a grind.
"Even though I finished in the top 10 in the Players Championship and then got through the group stages of the Match Play, I was always just sort of fighting my game a little bit, and then it's like you're sort of cramming for an exam.
"I started to practice harder than I would have liked in the days leading up to Augusta. I did something different this year, I went to Sage Valley and practised there Friday, Saturday and Sunday, then went and played nine holes at Augusta on Sunday evening.
"I think it all felt like it was a really long run-up. I think by Tuesday I felt pretty good with my game and then by Thursday I tanked a little bit."
The US PGA Championship moving from August to May means there is now a major championship every month from April to July and Rose is not the only player to have made adjustments to cope with the new schedule.
Masters champion Tiger Woods was expected to play at Quail Hollow this week but opted against it and will not compete between lifting his 15th major title and attempting to win a 16th in a fortnight's time at Bethpage, where he won the 2002 US Open.
"I was looking at the majors this year as 10-day blocks," former US Open champion Rose added. "I was going to go and try and do my preparation on the weekend, take sort of a Monday off and then get into the week.
"But I am going to switch that up. I'll probably do my preparation for next week much earlier than the weekend, a bit like I did for Merion back in 2013.
"I went up there for a few days midweek, really tried to get my head around the golf course, then came home for the weekend and tried to digest it, rest, spend some time with the family and head back up there early the next week."
Rose is one of three members of the world's top 10 competing in North Carolina, with world number four Rory McIlroy chasing a third victory in the event on his first start since finishing in a tie for 21st in the Masters.
