Tottenham scored early through Heung-min Son and in the second half through Giovani Lo Celso as they stifled Manchester City to win 2-0 and go top of the Premier League.
Victory for Spurs confirmed them as bonafide title challengers, with City rarely looking a threat throughout the 90 minutes.
Son's fifth-minute opener set the hosts on course for victory and though City will feel aggrieved to have had Aymeric Laporte's goal ruled out just before half-time, they were second best for much of the game.
Lo Celso's goal on the break, just 37 seconds after coming off the bench, midway through the second half made the game safe and secured another winner for Tom Carnduff, who tipped Tottenham to win at 3/1.
It was another Jose Mourinho masterclass, as he watched Tottenham produce one of his trademark performances.
Pep Guardiola’s men, on the other hand, dominated possession but were toothless.
The City boss signed a contract extension this week, but was not able to toast it with three points after his team failed to breakdown the disciplined and organised hosts.
It meant Mourinho, who celebrated a year in charge of Tottenham on Friday, again got one over his old rival to send the north Londoners back to the top of the table for at least 24 hours.
Mourinho had predicted Raheem Sterling would start for City despite being unavailable for England due to a calf injury, but he was only named on the bench where he was joined by the fit again Sergio Aguero.
Only five minutes had been played when Tanguy Ndombele threaded a pass into the path of Son, who ran into space vacated by Aymeric Laporte and Ruben Dias and slotted through the legs of the onrushing Ederson for his ninth league goal of the campaign.
The ball was in the away net again in the 13th minute; yet Kane had strayed into an offside position after a selfless Son pass.
Guardiola’s side thought they were level with 27 on the clock. Rodri’s cross into the area came through to Jesus, who set up the unmarked Laporte and the French defender drilled past Hugo Lloris from inside the area to make it 1-1.
No one had picked up the centre-back but Tottenham were saved by the pitchside monitor after VAR recommended Mike Dean use the technology to review if Jesus had used his arm to control the ball and City’s number nine duly had.
After the break, with pressure building, Mourinho replaced the excellent Ndombele with Lo Celso in the 65th minute. It was an inspired change with the Argentine scoring almost immediately, from another Kane assist.
Alderweireld found the England skipper in the middle of the pitch, who spotted Lo Celso had run away from De Bruyne and after the substitute took a touch into the area, he steered into the corner for his first ever Premier League goal.
Victory extended Spurs' unbeaten league run to eight games.
For City, in spite of a match in hand, they now trail the leaders by eight points and continue to lack a clinical edge in both boxes.