Liverpool defender Joel Matip faces up to six weeks out after suffering a fractured collarbone.
The 27-year-old sustained the injury in the closing moments of Tuesday night's 1-0 Champions League victory over Napoli and will now undergo surgery.
Matip had started the Reds' last three matches and has made 11 appearances in total this season.
With Joe Gomez already out for a similar period of time after fracturing his leg in the win over Burnley, the Premier League leaders now have just two fit senior centre-backs currently available.
One of those, Dejan Lovren, only made his return from concussion in the victory over Napoli, and is the only choice to partner Virgil Van Dijk.
An update from the Reds said: "Matip was taken to hospital following the fixture and further assessment deemed an operation is required.
"Early indications suggest the centre-back is facing a spell of up to six weeks out of action, though that is dependent on how Matip responds to his treatment and rehabilitation programmes."
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