James DeGale will defend his IBF world super-middleweight title against Caleb Truax, while IBF featherweight king Lee Selby faces Eduardo Ramirez on December 9.
Southpaw DeGale, 31, will make the fourth defence of his strap as he returns to action for the first time since January and a majority draw against Badou Jack.
Chunky underwent surgery on his right shoulder in June to repair a 180-degree tear, a rota-cuff tear and an ACJ stabilisation, an injury that had been troubling him for around two years - but he is now fit and ready to defend his world title on home soil for the first time at the Copper Box Arena after campaigning in America.
Minnesota native Truax (28-3-2, 18KOs) has mixed in good company, with his three losses coming at the hands of world-ranker operators Daniel Jacobs, Jermain Tayor and Anthony Dirrell.
"Truax is a good solid fighter with a top pedigree," said DeGale (23-1-1, 14KOs), who is three years younger than his opponent.
"He’ll be fighting away from home so he’s going to bring it on and try to take my world title, but I’m the best super-middleweight in the world and I'm going into the ring full of confidence and 100 per cent fit.
"I've not boxed in London for a few years so I can’t wait to make my return to the ring, soak up the atmosphere from the crowd and put on great show."
It will also be a fourth title defence for Welshman Selby (25-1, 9KOs) who knows victory will set up a domestic showdown with Leeds Warrior Josh Warrington, who is his number one mandatory challenger.
Mexican southpaw Ramirez (20-0-3, 7KOs) is trained by Manuel Montiel Jr, brother of five-time world champion Fernando who Selby beat just over two years ago.
"Ramirez is a very good unbeaten fighter and he comes from a good stable," said 30-year-old Selby.
"He has a decent ranking with the IBF and you don’t get there by accident, he’s worked his way into the mix and he’s going to give me a tough test. He’s a southpaw which is another challenge for myself.
"There’s a lot of pressure on this fight, one loss will mess up my whole career. There’s massive fights to be made against Warrington and Carl Frampton next year so it’s vital that I come through this fight."