Anthony Crolla will challenge WBA and WBO lightweight champion Vasiliy Lomachenko in Los Angeles on April 12, Matchroom has confirmed.
The Manchester boxer, a former WBA champion, will take on the man widely regarded as the sport's pound-for-pound king at Staples Center.
It will be the 32-year-old's second professional bout in the United States and first since 2011.
Crolla lost the WBA title to Jorge Linares in 2016 and was also beaten in a rematch the following year, but victories over Ricky Burns, Edson Ramirez and Daud Yordan has put him back in the title picture.
Eddie Hearn, managing director of Matchroom Sport, said: "After losing his world title to Jorge Linares, Anthony has fought his way back into the mandatory position and he is more than ready for the challenge."
Lomachenko, a three-weight world champion, added the WBA belt to his WBO title when he beat Linares at New York's Madison Square Garden in May.
Crolla said: "I cannot wait for this, these are the fights you are in the sport for.
"People will say that I have got nothing to lose but I am genuinely going over to LA to shock the world."