Roger Federer's quest for a sixth Wimbledon title gathered pace with an emphatic 6-2 6-2 6-4 win over Guillermo Garcia-Lopez.

The Swiss second seed wrapped up victory in 89 minutes and will take on Philipp Kohlschreiber for a place in the last 16 after the German ousted Ivo Minar in a five-set thriller.

"I thought all the sets were pretty similar, he won the first service game and I broke him in the next," said Federer, neatly summing up the pattern of an underwhelming match. "I thought one end (of the court) was definitely easier to play from.

"I definitely did not want to underestimate him but I think I did well today, I could even try out a few things in the third set. It was solid and that's exactly what I needed today.

"I expected a much harder match because he's been playing well in Eastbourne, he reached the semis over there. And I've played him twice before where I saw he has some good forehands and steady backhand. On grass you never know so I was quite surprised I was able to win so easily today."

World number four Novak Djokovic had little trouble overcoming unseeded German Simon Greul in their second round clash on Court One.

The 7-5 6-1 6-4 victory sees the fourth seed surpass his previous performance at the All England Club when he was defeated at the same stage last year by Marat Safin.

The Serbian followed up his first round victory over Julien Benneteau with a more assured display against Greul to set up a third round meeting with American Mardy Fish.

Serve and volley specialist Fish, seeded 28, overcame Serbian Janko Tipsarevic 6-4 3-6 6-1 6-4 in an entertaining match on Court Two.

Spanish seventh seed Fernando Verdasco was made to work before he prevailed a 7-6 6-7 7-6 6-4 victor over Belgium's Kristof Vliegen.

Verdasco, who is ranked 74 places higher than his Belgian opponent, was taken to three tie-breaks before eventually prevailing in four sets.

Australian Open semi-finalist Verdasco will face compatriot and 32nd seed Albert Montanes - a 6-4 6-3 4-6 6-3 winner over Guillermo Canas - in the third round.

Number nine seed Jo-Wilfried Tsonga was earlier the first player to reach the third round of Wimbledon after last 64 opponent Simone Bolelli withdrew through injury.

French number two Tsonga, who reached the final of the Australian Open in 2008, will face Croatian 22nd seed Ivo Karlovic after he saw off Steve Darcis, for a place in the last 16.

Germany's Rainer Schuettler was the first male seed to crash out at the second hurdle. The number 18 seed and 2008 semi-finalist was blown away in straight sets by Israel's Dudi Sela 7-6 6-3 6-2.

The reward for Sela's victory is a third round clash with number 15 seed Tommy Robredo.

The Spaniard produced an inspired comeback to fight back from two sets down to outlast Austrian Stefan Koubek 3-6 4-6 6-4 7-6 6-1 in a marathon second round clash.

Unseeded Frenchman Michael Llodra was forced to quit his second-round match against Tommy Haas after a heavy collision with a ball girl.

Llodra required medical attention and had to retire from the match at 4-3 behind in the first set, allowing Germany's 24th seed Haas to advance to the last 32.

Marin Cilic will be the German's opponent in the next round after he secured a 4-6 7-6 6-3 6-7 6-4 victory over Sam Querry in the last men's singles match to finish on Wednesday night.

French Open finalist Robin Soderling was a winner as he defeated Marcel Granollers in four sets and he will now face Nicolas Almagro, who was made to work hard for a 6-4 7-6 3-6 3-6 7-5 victory against Karol Beck.

In the women's draw, former Wimbledon champion Maria Sharapova has been dumped out of this year's tournament by unseeded Gisela Dulko.

The 24th seed, still recovering from a long injury lay-off, struggled greatly in the first set and a half before mounting an admirable comeback but eventually lost 6-2 3-6 6-4.

Shrapova made a very slow start on Centre Court, losing the first three games of the match and dropping serve twice in the first set.

The Russian looked to be heading for a drubbing when she lost her serve again at the start of the second set but she fought back to win six straight games and take the match into a decider.

A back-and-forth third set ensued, with Dulko eventually prevailing after squandering four match points on her serve.

"It's the biggest win of my career because she's a great champion and on Centre Court in the most important tournament in the world," the 24-year-old said after the match.

There were no such problems for second seed Serena Williams, who blasted her way past Australian player Jarmila Groth in less that an hour.

The double Wimbledon champion lost only three games en route to a comprehensive 6-2 6-1 victory.

As Groth struggled with double-faults, Williams was almost unstoppable on serve, sending down five aces and winning 71 per cent of her service points.

Nadia Petrova booked her place in the third round of Wimbledon with a comfortable 6-3 6-2 win over Shahar Peer.

The Israeli player failed to get into her stride and was overpowered by the 10th seed in a match that lasted only one hour and 10 minutes.

Slovakia's Daniela Hantuchova, who escaped an upset against Laura Robson on Monday, produced a shock of her won by beating Zheng Jie 6-3 7-5.

In a match that saw a total of eight breaks of serve, the world number 32 triumphed 6-3 7-5.

Eighth seed Victoria Azarenka handed out a thrashing to Romanian Ioana Raluca Olaru, winning every single game in a 6-0 6-0 double-bagel victory.

Seventh seed Vera Zvonareva was not quite so commanding in victory but recorded an extremely comfortable 6-3 6-1 win over Mathilde Johansson none the less.

Dominika Cibulkova, also of Slovakia, had an easier route through to round three as she brushed aside Urszula Radwanksa 6-2 6-4 on Court Seven.

Japanese veteran Ai Sugiyama disposed of Spain's Arantxa Parra Santonja 7-6 6-3 in a clash between two unseeded players.

Russian seed Anastasia Pavlyuchenkova crashed to defeat on day three, losing out 6-4 7-6 to 26-year-old Italian Roberta Vinci.

Indian number one Sania Mirza failed to progress into the third round as she suffered a 6-4 6-4 straight-sets defeat to 28th seed Sorana Cirstea.

In an all-Russian clash, 27th seed Alisa Kleybanova came unstuck against Regina Kulikova as the 20-year-old fought back from a terrible start to win 0-6 6-4 6-1.

Elena Dementieva of Russia, the fourth seed, also reached the last 32 with a 6-1 6-3 victory against France's Aravane Rezai.

Dementieva took the first setcomfortably before running into trouble early in the second, however she lifted her performance to gain the anticipated straight-sets win.

Former finalist Marion Bartoli joined her in the third round, defeating Swiss player Timea Bacsinszky 7-5 6-1.

Bartoli, seeded 12th this year, was the surprise runner-up in 2007.