Reigning champion Venus Williams crashed out of Wimbledon on Saturday.

Williams, who had played in five of the previous six finals, blamed a wrist injury for her 7-6 4-6 6-4 defeat by 21-year-old Jelena Jankovic, from Belgrade, on Wimbledon's infamous court two, the 'graveyard of champions'.

Williams said: "I wasn't able to play my best. I was having problems with my left wrist. It made it very tough.

"I've played her a couple of times before. Against a player like me, I guess she feels like she has nothing to lose.

"She came out and gave it her all. She played well."

Briton Andy Murray stormed into the fourth round for the first time with a sensational straight-sets win over two-time finalist Andy Roddick on Centre Court.

Murray made a mockery of Roddick's reputation as the biggest server in the game by breaking the American three times on his way to a 7-6 6-4 6-4 win in exactly two and a half hours.

It was a performance which not only sent Murray into the last 16 but emphatically underlined his status as a genuine future Grand Slam title contender.

Murray said: "I played a great match today. I wasn't expecting to win although I did feel I had a slight chance if I served well.

"I'm really happy to come through and to win in three sets is pretty special.

"To get into the second week of a Grand Slam for the first time is great.

"I am not used to being around the locker room when only 16 people are left and I am really looking forward to Monday."

Murray will meet Marcos Baghdatis, who toppled Sebastien Grosjean in four sets, in the last 16.

Andre Agassi bade an emotional farewell to Wimbledon after losing in the third round to Rafael Nadal.

Agassi, who won his first Grand Slam title at the All England Club in 1992, was beaten 7-6 6-2 6-4 by a player who was just a year old when Agassi made his Wimbledon debut in 1987.

The 36-year-old will now hope to go out on a high when he plays his last event before retiring at the US Open later this year.

Agassi told a packed Centre Court crowd: "It's been a lot of incredible years here, I'll never be able to repay you for how you've embraced me over the years. I thank you for that.

"This is it for us, if you dream about being a professional tennis player you dream about being right here.

"I've had the privilege of being here many times and this is one I won't forget.

"Coming back this year I didn't know what to expect from myself but one thing I felt I could count on was how you've always been to me over the years and I thank you for that."

Nadal will now meet Irakli Labadze, who won when Mardy Fish retired after losing the first set.

Labadze, who ousted former French Open champion Gaston Gaudio in the first round, had won the opening set 6-2 against his American opponent.

Lleyton Hewitt made short work of Olivier Rochus to advance to the last 16.

The Australian dominated the opening exchanges and although Rochus rallied, Hewitt wrapped up a 6-1 6-4 6-4 success in one hour and 58 minutes on Court Two.

Rochus, at 5ft 5in the shortest player on the ATP Tour, had no answer to Hewitt's greater weight of shot and the sixth seed now faces a fourth round contest against David Ferrer who put out Fernando Gonzalez.

The Spaniard fought back from two sets down to win in five.

Russia's Dmitry Tursunov was a heroic five-set winner over fifth seed Ivan Ljubicic.

Tursunov, the 27th seed, fell two sets behind and looked to be on his way out before a spirited fightback on Court One.

Seventh seed Mario Ancic finally saw off Stanislas Wawrinka on Court One.

The pair started their match on Friday but bad light had forced them off with the scores level at one-set all.

When they resumed Ancic, the last man to beat Roger Federer in SW19, was in rampant mood as he took the third set for the loss of just one game.

The writing was on the wall when 'Super Mario' broke early in the fourth, and the big-serving Croatian closed out for an impressive 7-6 (7-5) 6-7 (5-7) 6-1 6-3 win.

He next meets young Serbian star Novak Djokovic.

Finn Jarkko Nieminen is also through after a tough four-setter against Phillip Kohlschreiber, the 22nd seed coming through 1-6 6-2 6-3 7-6 (7-4).

Back in the ladies' singles, top seed Amelie Mauresmo continued her fine form with a 6-1 6-2 win over Australian qualifier Nicole Pratt.

The world number one and Australian Open champion never looked back after surviving a break point in the first game. She quickly moved 3-0 ahead and went through the gears to wrap up an impressive victory.

Maria Sharapova kept a half-full Centre-Court crowd entertained as she brushed aside 33-year-old Amy Frazier to reach the fourth round.

The show court, packed to the rafters to witness Agassi's Wimbledon farewell, rapidly emptied in time for another American veteran arrived to take his place.

Sharapova, the 2004 champion who had dropped just six games and spent under two hours on court in her first two matches, was at least forced to break sweat under the hot sun before clinching a 6-3 6-2 win.

Anastasia Myskina made short work of Spain's Anabel Medina Garrigues to reach round four, winning 6-3 6-4.

Elsewhere Elena Dementieva won a gruelling all-Russian battle with Elena Likhovtseva on Court Two.

Dementieva toughed out the first set 7-5 and after establishing a lead early on in the next never looked back as she punched out a 7-5 6-3 win.

She now meets American Shenay Perry, who was also a 7-5 6-3 winner against Sybille Bammer.

Ana Ivanovic came back from a set and a break down to see off Dinara Safina.

Safina won the opening set 6-3 and was a break up early on in the next.

However Ivanovic levelled up with some powerful hitting to force a second set tie-break, which she duly won.

The Serb then raced away with the decider to come through 3-6 7-6 (6/3) 6-1.

Finally, 16th seed Flavia Pennetta crushed Shuai Peng 6-2 6-3 to book her place in the fourth round.