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Tim Henman reached the quarter-finals of Wimbledon for the seventh time in eight years after defeating Argentina's David Nalbandian on Centre Court.

The British number one won 6-2 6-7 (4-7) 7-5 6-3 against the sixth seed from South America, who was beaten in last year's final by Lleyton Hewitt.

Henman next plays either third seed Juan Carlos Ferrero of Spain, or Sebastien Grosjean from France.

The Frenchman took the first set easily 6-2, but Ferrero battled back to take the second 6-4.

Grosjean had just won a third-set tie-break when the end came.

Andre Agassi was sent crashing out of the tournament in the face of a barrage of aces from big-serving Mark Philippoussis.

The Australian, nicknamed 'Scud' produced a stunning performance to win a five-set thriller on Court One.

He slammed down 46 aces as he edged into the last eight with a 6-3 2-6 6-7 6-3 6-4 victory.

Agassi looked to be on his way through when he won the third-set tie-break in impressive fashion, but he didn't count on the serving assault continuing.

The key break in the decider came in the seventh game and although Agassi forced break points in the very next game, the 33-year-old could not take them and bowed out.

"It's definitely up there among my best wins," said Philippoussis. "It's extremely important for me.

"He has beaten me the last six times in a row and to finally get him in the way I did was great.

"I felt I had nothing to lose, everyone expected him to win and that's a great position to be in.

"I'm extremely pleased with the outcome today but it's nothing to get excited about.

"I have a quarter-final match to concentrate on and I need to take the pluses from this match and put it into the next one."

Meanwhile, Agassi conceded Philippoussis "was definitely the better player today at the right time".

The veteran Las Vegan insisted he had every intention of returning to Wimbledon next year.

"Why wouldn't I be back? I am still a tennis player and this is the place to be."

But he did admit: "It's not easy to win Wimbledon.

"For it to happen again would be quite an amazing thing."

Agassi's defeat is good news for Tim Henman as the two were due to meet in the semi-finals.

Earlier in the day Andy Roddick - currently favourite to lift the men's title - dropped his first set of the tournament but still had too much for Paradorn Srichaphan.

The Thai star managed to level the match after dropping the first set.

He also had chances to go a break up in the third, but once Roddick had saved them, the American eased to a 6-4 3-6 6-3 6-2 victory.

Roddick will now face Jonas Bjorkman in the quarter-finals.

The Swede progressed by putting out 'the Beast of Belarus', Max Mirnyi, in four sets.

Roddick, who lost to Bjorkman on grass at Nottingham last year, knows he will need to on top of his game against the serve-and-volley expert.

"He's a good player and has won matches for years and years. He's going to try to be all over the net. He's not going to want to stay back too much.

"I lost to him last year on grass so I'm definitely looking to get a win here."

Roddick is seeded to play Roger Federer in the semi-finals, but that meeting looked in doubt when the Swiss star needed early treatment on a back injury against Feliciano Lopez.

The 'Fed Express' called for the trainer just two games into the match, but recovered from a sluggish start to reach the next round.

It might have been a different story had Lopez managed to serve out the first set at 5-4, but instead Federer broke straight back and took the opener on a tie-break.

He didn't look back and went on to win 7-6 (7-5) 6-4 6-4.

But things did not look good for his future in the tournament when he admitted afterwards: "I was always under a lot of pain and I don't know how I won today.

"It (the back injury) happened in the warm-up - I just couldn't move any more so I had to call the trainer and hope for a wonder.

"I didn't think I would sit here as the winner after the shock I had.

"As the match went on it got a little bit better but I'm a little bit exhausted because of everything that happened.

"So I have to try to take this lucky, lucky match and get rid of this and be ready for the quarters."

Injury permitting, Federer will now play eighth seed Sjeng Schalken, who continued his quiet progress through the draw by overcoming Rainer Schuettler in straight-sets.

The Dutch star secured a place in the quarter-finals for a second consecutive year with a 7-5 6-4 7-5 win over the Australian Open runner-up.

Also through to the last eight is the big-serving Alexander Popp.

The German, who made the last eight on his only other SW19 appearance in 2000, returned to the quarter-finals as he saw off Olivier Rochus, winning 5-7 6-3 6-4 6-2.

Popp is Philippoussis' next opponent.

Defending champion Serena Williams led the women's big names into the quarter-finals.

The top seed looked in imperious form as she crushed Elena Dementieva 6-2 6-2 on Centre Court.

She now faces a rematch against old foe Jennifer Capriati - the last player to beat her at the All England Club.

Capriati made a blistering start against 10th seed Anastasia Myskina, racing 4-0 up - a position she was determined not to blow.

She went on to complete a 6-2 6-3 victory and set up that mouthwatering quarter-final clash.

It will be a repeat of their quarter-final encounter in 2001 when Williams was derailed by a combination of the brimming momentum of Capriati's spectacular comeback and a day on which she herself felt unwell.

"I was watching her in the first and second rounds and she was playing really well," said Williams.

"My dad and I were talking about how well she's doing and I definitely expected to meet her in the tournament.

"I've not been overlooking Jennifer. Her return is working really well and she's staying really low on the grass. That's really important but it's hard to stay low all the time."

Capriati was also relishing the clash.

She said: "I'm just gonna be really psyched up and just apply everything that I've been doing and hopefully it will be the same, things won't change in my game, and I can continue to be aggressive and serve well.

"We've had some great matches in the past and usually we have great matches.

"I just know it will be a fight again."

Williams' victory came hot on the heels of Kim Clijsters' win.

Like her American rival, the Belgian wasted little time in progressing.

Clijsters, seeded second, raced to a 6-3 6-2 victory over her doubles partner Ai Sugiyama on Court One.

In the process, Clijsters became the quickest player in 21 years to reach 50 wins in a season.

The world number two is not concerned at the ease of her progress through the draw.

She said after the match: "The way I'm playing my confidence is really high at the moment and I don't mind having these quicker matches because they are better than tough long ones."

Next up for her is a meeting with 27th seed Silvia Farina-Elia. The Italian put out Paola Suarez 7-5 7-6.

The top two seeds were soon joined in the last eight by former champion Lindsay Davenport.

The 1999 winner, seeded fifth this year, was made to fight hard in the first set by Shinobu Asagoe.

But serving well, she clinched it 6-4 and then swept through the second 6-1 to set up a clash with Venus Williams.

Davenport said: "I feel good and I've reached the quarter-finals which was my target here but now it gets tough obviously.

"Venus has beaten me the last two times here and is probably the best grass-court player, right up there with Serena."

The elder of the Williams sisters took revenge for her defeat against Vera Zvonareva at the recent French Open by beating the Russian 6-1 6-3 after rain had delayed the start on the outside courts.

Williams played down the revenge factor in her win and revealed that she was unhappy with her performance.

"The last time she was the better player and this time it was nice that I was able to win.

"But I would have liked to have played better. I was a bit off my game. It's impossible to play perfect every match. It's a bit of a relief to have an 'off' match so now I can have 'on' matches."

After another rain interruption, Justine Henin-Hardenne continued her winning run by ending the hopes of Mary Pierce.

The current French Open champion had too much class for the 2000 title winner and secured a comfortable 6-3 6-3 win.

She will now face Svetlana Kuznetsova after the Russian ended 16-year-old pin-up girl Maria Sharapova's dream debut run.

The former world junior champion emerged from a tight contest as a 6-1 2-6 7-5 winner.