Chris Hicks grabbed a hat-trick of tries for the second successive week as Warrington smashed Huddersfield's nine-month winning away record.
Hicks followed his treble in the 58-22 romp at Bradford with a first-half hat-trick to inflict on the Giants a first away defeat since they lost at Leeds last July.
The Giants had won 10 games in a row but missed the chance to climb to second in Super League.
Hicks, Warrington's 10-try leading scorer was indebted to a classic centre show from the outstanding Chris Bridge.
Warrington made a whirlwind start and were 10-0 ahead after only four minutes.
Skipper Adrian Morley's smart offload enabled slick passing to send Matt King over before Bridge's expertise gave Hicks his first try.
Huddersfield briefly threatened a comeback when Paul Johnson spilled Kevin Brown's high kick and Simon Finnigan went over to cut the gap to 10-6.
But their joy was short lived as Warrington led 20-6 at half-time with two more tries from Hicks courtesy of passes from Ben Westwood and Bridge.
Hicks was denied a fourth try after a smart flick pass from Bridge was adjudged to be forward.
Warrington confirmed their superiority in the second half with Chris Riley bagging two tries and Michael Monaghan going over.
Huddersfield did manage touchlines from Paul Whatuira and Brett Hodgson but could have no complaints after being outplayed.
Hicks, who plundered 30 points against Bradford last week, also booted six goals from nine attempts to finish with another impressive haul of 24 points.