Clint Greenshields' early sinbinning cost Catalans dear as Bradford marched into the Challenge Cup quarter-finals with a clinical 46-16 demolition of last season's beaten finalists.
The Dragons full-back was sent to the bin in the fifth minute for holding down opposite number Michael Platt in Bradford's first meaningful attack and the Bulls made their numerical advantage pay in spectacular fashion.
They ran in four tries during Greenshields' enforced absence as Semi Tadulala quickly broke the French side's resistance to claim the first of his three touchdowns before Sam Burgess and Dave Halley added further scores.
Tadulala then crossed again and with Paul Deacon converting all four tries, the Catalans were 24-0 down when Greenshields walked sheepishly back onto the field in the 15th minute.
It was no way for the 26-year-old Australian to mark his new three-year deal but in truth it looked a harsh decision and he recovered well to claim his side's first try in the 28th minute.
It was not nearly enough, however, and Mick Potter's men shipped a fifth score before the break when Deacon sent Chris Nero clear.
Jamie Langley, Shontayne Hape and Tadulala added three more tries in the second half to seal a comprehensive victory which took the Bulls a step closer to their first Challenge Cup final since 2003, when they defeated arch-rivals Leeds in Cardiff.
Danny McGuire's hat-trick broke Harlequins' hearts and sent Leeds Rhinos into the quarters-finals after they won a thriller 36-26 at The Stoop.
Quins had battled back from 24-4 down to take a 26-24 lead with three minutes remaining but Great Britian captain Jamie Peacock and McGuire spared the Rhinos' blushes with late tries to stun the brave hosts.
Hull KR overcame a disastrous start to comfortably book their place in the last eight by beating Huddersfield 44-22 in their fifth-round tie at Craven Park.
Huddersfield, the 2006 runners-up, made a dream start by racing into a 12-0 lead after 17 minutes but finished a well-beaten side and, with just two wins from their last 11 matches, this result can only increase the pressure on coach Jon Sharp.
It was 22-22 until Rovers winger Peter Fox scored the second of his two tries on 53 minutes but two late tries emphasised the home side's superiority.
Willie Manu's 60th-minute try proved to be the difference as Hull FC booked their place in the quarter-finals by beating Widnes 32-18.
Widnes were showing signs of possibly causing a cup upset but Manu's blockbusting effort settled things for Peter Sharp's men.
The National League side put in a monumental effort against Super League Hull but it unravelled in the final quarter.
They kept themselves firmly in it until the 70th minute but Hull had enough in their locker to put Widnes to the sword.
Wakefield showed the gulf in class between the engage Super League and National Division Two with a 58-6 victory over Barrow to book their place in the quarter-finals.
Wakefield ran in 10 tries with Danny Brough, Ryan Atkins and Kyle Bibb all crossing twice.
Brough also kicked nine goals to score a total of 26 points. Darren Holt scored a consolation try for the visitors.
Oldham cruised into the quarter-finals with a comfortable 58-12 victory over First Division side Dewsbury Rams.
The Second Division side ran in 10 tries, seven of which came in a stunning second-half display.
Man-of-the-match second row Tommy Goulden led the way with four tries, there was a brace a piece for scrum-half James Coyle and centre Mick Nanyn while Lucas Onyango and Richard Mervill also crossed.
Nanyn capped a fine game by landing nine conversions from ten attempts for a personal haul of 26 points.
Pat Walker and Dominic Maloney replied with tries for Dewsbury, both converted by Walker.
St Helens remain on course for a third successive Challenge Cup after maintaining their dominanace over local rivals Warrington with a 40-34 victory in a gripping fifth-round tie.
The holders produced a carbon copy of their 30-22 victory at Warrington a fortnight earlier by coming from behind three times to complete a third derby win of the season at the re-named GPW Recruitment Stadium.