Aviva Premiership statistics
Sunday, November 25
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Tom Homer is selected at full-back by London Irish while number eight Chris Hala'ufia and lock Bryn Evans return after being rested against Leicester.
Exeter give Jack Nowell his Premiership debut on the right wing as Gonzalo Camacho is on international duty with Argentina.
Last season: Exeter 18 London Irish 11, London Irish 29 Exeter 22
Last six league matches: London Irish L W L W L L Exeter L W L W L W
Top try scorers: Halani Aulika, Jonathan Joseph & Topsy Ojo (London Irish) 2; Matt Jess (Exeter) 4
Top point scorers: Ian Humphreys (London Irish) 78; Gareth Steenson (Exeter) 59
Centre Anthony Allen and number eight Thomas Waldrom return to Leicester's starting line-up after being released by England. Club captain Geordan Murphy is included on the bench.
Wasps are boosted by the return of half-backs Joe Simpson and Nick Robinson and openside Jonathan Poff from the treatment room.
Last season: Leicester 29 Wasps 11, Wasps 35 Leicester 29
Last six league matches: Wasps W L L W W L Leicester D L W W L W
Top try scorers: Tom Varndell & Christian Wade (Wasps) 6; Adam Thompstone (Leicester) 3
Top point scorers: Nicky Robinson (Wasps) 70; Toby Flood (Leicester) 122