London Welsh's first season in Europe was ended at the pool stage after they slipped to a 27-13 defeat against Grenoble at the Kassam Stadium.
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The French club put their off-field troubles aside with a bonus-point victory that left runaway Pool Five leaders Stade Francais Paris eight points clear and with one foot in the quarter-finals.
Grenoble, stripped of the points from their 20-9 result in round three after being found guilty of fielding an ineligible player, took the lead with a penalty goal from Valentin Courrent and the scrum-half quickly added a conversion.
That kicking opportunity came courtesy of hooker Laurent Bouchet crossing the Exiles' line and the front-row proved that was no fluke when he added another eight minutes later.
Fly-half Alex Davies kept London Welsh in the game up to the break with two penalties but the gap was quickly restored two minutes into the second half when Florian Ninard touched down.
Replacement flanker Mike Denbee crossed for an Exiles try that Davies converted, but Feliuaki Taukeiaho claimed a bonus point six minutes from time.