Wales will attempt to end their Six Nations campaign on a high note when they face Scotland at the Millennium Stadium on Saturday.
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Warren Gatland's side saw their hopes of retaining the title they have held since 2012 disappear with a 29-18 defeat to England at Twickenham last weekend.
They were given a further blow after the game with the news that Leigh Halfpenny will miss the summer tour of South Africa after dislocating his shoulder.
But a big win against Scotland would help ease some of the pain and would provide a welcome morale boost.
Gatland has made six changes to his starting XV, with Liam Williams named as his starting full-back in Halfpenny's absence.
Dan Biggar takes over the No 10 shirt from Rhys Priestland, while Richard Hibbard and Adam Jones are replaced in the front row by Scarlets duo Ken Owens and Rhodri Jones.
An ankle injury suffered by Rhys Webb means Mike Phillips is recalled at scrum-half, while lock Luke Charteris has passed a fitness test on his neck injury and comes in for Jake Ball.
Prop Gethin Jenkins retains his place in the side and will win his 105th cap on Saturday, overtaking former fly-half Stephen Jones at the top of Wales' all-time appearance chart.
"Gethin is one of the most intelligent rugby players in his position in the history of the game," Wales assistant coach and defence specialist Shaun Edwards said.
"He is an all-round rugby player, not just a prop forward who scrummages, but one of the first players I go to at half-time and have a chat about anything he thinks we need to be concentrating on. I totally respect his opinion.
"For Gethin and a sold-out capacity crowd we will have won all our home games if we win tomorrow, but we know Scotland are a big challenge."
Scotland head into the clash looking for a success which would match last year's tally of two victories in the competition.
They are unlikely to finish in the wooden spoon position as Italy need to clinch an unlikely win over England to avoid ending their campaign bottom of the pile.
Outgoing interim head coach Scott Johnson has made three changes to his starting line-up, with the most notable of those seeing Edinburgh wing Dougie Fife win his first cap after being brought in for the injured Tommy Seymour.
"It (Millennium Stadium) is a fantastic place, one of the world's best. I am really looking forward to it," Johnson said.
"We want a good show. It goes without saying you would love to win, but if we get a win and we win ugly we will acknowledge that we didn't play well.
"Last week (against France) I thought we were the better team and we didn't get the win. It happens. We want a good performance, and to be fair, I think we need one to win."
Wales: 15 L Williams, 14 Cuthbert, 13 Davies, 12 Roberts, 11 North, 10 Biggar, 9 Phillips; 1 Jenkins 2 Owens, 3 R Jones, 4 Charteris, 5 A-W Jones, 6 Lydiate, 7 Warburton (c), 8 Faletau.
Replacements: 16 Hibbard, 17 James, 18 A Jones, 19 Ball, 20 Tipuric, 21 R Williams, 22 Priestland, 23 Hook.
Scotland: 15 Hogg, 14 Fife, 13 Dunbar, 12 Scott, 11 Evans, 10 Weir, 9 Laidlaw; 1 Grant, 2 Lawson, 3 Cross, 4 Gray, 5 Hamilton, 6 Wilson, 7 Brown (c), 8 Denton.
Replacements: 16 Ford, 17 Dickinson, 18 Murray, 19 Swinson, 20 Strokosch, 21 Cusiter, 22 Taylor, 23 Cuthbert.