Alex Corbisiero will make his first start of the season when London Irish host Sale Sharks in LV= Cup action on Sunday.
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The England prop has now fully recovered from a knee injury sustained whilst on international duty in South Africa during the summer and is picked in the front row for the game at the Madejski Stadium.
Corbisiero is not the only player to be starting for the Exiles for the first time in the campaign, with Shane Geraghty selected at inside centre.
Geraghty has made five substitute appearances in his second spell with the capital club but gets the chance to impress from the off this time, director of rugby naming him alongside Guy Armitage in Irish's midfield.
Sale, meanwhile, will be looking for history to repeat itself - they defeated London Irish 21-9 last Friday to record their first win in the Aviva Premiership.
The much-changed visitors will be captained by scrum-half Dwayne Peel, though Danny Cipriani is retained alongside his skipper in the No.10 jersey.
Props Eifion Lewis-Roberts and Vadim Cobilas both start after coming off the bench at Edgeley Park last time out; Tommy Taylor is retained at hooker.
James Gaskell also get a starting berth in the second row while Andy Powell's selection means Richie Vernon switches to the number seven shirt. The pair are joined in the back row by Mark Easter.
London Irish: 15. Anthony Watson; 14. Topsy Ojo; 13. Guy Armitage; 12. Shane Geraghty; 11. Sailosi Tagicakibau; 10. Ian Humphreys; 9. Darren Allinson; 1. Alex Corbisiero; 2. Brian Blaney; 3. Leo Halavatau; 4. George Skivington; 5. Bryn Evans (Captain); 6. Matt Garvey; 7. Jamie Gibson; 8. Chris Hala'ufia
Replacements: 16. Gerard Ellis; 17. Jerry Yanuyanutawa; 18. Cai Griffiths; 19. Kieran Low; 20. Alex Gray; 21. Conor Gaston; 22. Steven Shingler; 23. Jack Moates
Sale Sharks: 15.Rob Miller, 14.Charlie Amesbury, 13.Will Addison, 12.Mark Jennings, 11.Cameron Shepherd, 10.Danny Cipriani, 9.Dwayne Peel (Captain), 1.Eifion Lewis-Roberts, 2.Tommy Taylor, 3.Vadim Cobilas, 4.Fraser McKenzie, 5.James Gaskell, 6.Andy Powell, 7.Richie Vernon, 8.Mark Easter
Replacements: 16.Tom Cruse, 17.Ross Harrison, 18.Tony Buckley, 19.Kearnan Myall, 20.Will Bordill, 21.Will Cliff, 22.Jordan Davies, 23.Corne Uys
What they said...
London Irish director of rugby Brian Smith
"We will be picking the strongest side possible for Sunday. We are going into the LV= Cup with the intent to go as far as we can.
"Regardless of whether it's the Aviva Premiership, JP Morgan Sevens, the Amlin Challenge Cup or the LV=Cup, we want to win trophies.
"Consequently we'll be selecting very strong teams to play in every competitive match this season. There is risk associated with this strategy but we are trying to build a winning culture so there is method in the madness."